Results 91 to 100 of about 2,779,005 (316)

The influence of cultivation technologies on the contamination of spring wheat crops and yield in the conditions of the Nizhny Novgorod region

Аграрная наука Евро-Северо-Востока
The article presents the results of research of the influence of various cultivation technologies on the contamination of spring wheat crops and its yield for 2022–2023 in the conditions of the Nizhny Novgorod region on light gray loamy forest soil ...
A. V. Ivenin, V. V. Ivenin, Yu. A. Bogomolova, S. M. Golubev, I. I. Bugrov   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A homothetic data generated technology

European Journal of Operational Research
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Is a general extended technology acceptance model for e-learning generalizable?

Knowledge Management & E-Learning: An International Journal, 2018
e-Learning acceptance has received considerable attention in the educational technology literature. In recent years, many frameworks have been proposed, modified, and applied to better understand the factors underlying students’ acceptance of e-learning.
Tenzin Doleck, Paul Bazelais, David John Lemay   +2 more
doaj  

Visual Surveillance Within the EU General Data Protection Regulation: A Technology Perspective

IEEE Access, 2019
From an individual's perspective, technological advancement has merits and demerits. Video captured by surveillance cameras while a person goes about their daily life may improve their personal safety but the images collected may also represent an ...
Mamoona N. Asghar, Nadia Kanwal, Brian Lee, Martin Fleury, Marco Herbst, Yuansong Qiao   +5 more
doaj   +1 more source

An anthropological study based upon observations of complexion and cephalic measurements of students at the Massachusetts Institute of Technology

, 1896
Thesis: B.S., Massachusetts Institute of Technology, Department of General Studies, 1896by Harry George Fisk, James George Melluish.B.S.B.S.
Fisk, Harry George., Melluish, James George.   +1 more
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Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Handbook of the Massachusetts Institute of Technology [PDF]

, 1943
The Handbook of the Massachusetts Institute of Technology was produced by the Technology Christian Association and provided general information about MIT extra-curricular activities and area ...
​​Massachusetts Institute of Technology
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