Results 61 to 70 of about 7,828,899 (356)
Technology enhanced interaction framework
, 2013 This paper focuses on the development of a general interaction framework to help design technology to support communication between people and improve interactions between people, technology and objects, particularly in complex situations.
Angkananon, Kewalin +2 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Technology assessment of advanced automation for space missions [PDF]
, 1982 Six general classes of technology requirements derived during the mission definition phase of the study were identified as having maximum importance and urgency, including autonomous world model based information systems, learning and hypothesis ...
core +1 more source
General Purpose Technology and Wage Inequality [PDF]
, 2014 The recent changes in the US wage structure are often linked to the new wave of capital-embodied information technologies. The existing literature has emphasized either the accelerated pace or the skill-bias of embodied technical progress as the driving ...
Aghion, Philippe +2 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
THE TECHNOLOGY OF THE INTEGRAL SCIENTIFIC ACTIVITIES
Sovremennye Issledovaniâ Socialʹnyh Problem, 2014 Based on complete-approach of kompletiks formulated the principle of the integrity of the technology research activities and created a general model of the complex technology of research activities, ranging from the formation of technology design and ...
Marat Makhmetovich Telemtaev +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
General multiyear aggregation technology: Methodology and software documentation [PDF]
A general methodology is presented for estimating a stratum's at-harvest crop acreage proportion for a given crop year (target year) from the crop's estimated acreage proportion for sample segments from within the stratum. Sample segments from crop years
Baker, T. C.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Information Technology in General Practice: current use and views on future development
Journal of Innovation in Health Informatics, 1997 Objective: To ascertain general practitioners current use of computers and their views on future development of information technology in general practice. Design: Postal questionnaire sent to general practitioners.
Arfan Ahmed, Anita Berlin
doaj +1 more source