Results 61 to 70 of about 72,758 (215)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Effects of Blockchain Technology on Corporate Governance: Evidence from Emerging Economy
Management Dynamics in the Knowledge Economy, 2022 Modern developments in digitization have completely changed business structures and operating procedures. The core structure of a database can be built using the distributed technology known as blockchain, which combines data blocks and hash chains ...
Grace Osariemen EGHE-IKHURHE +1 more
doaj
Towards a technocratic governance system?
International Journal of Innovation Studies, 2019 The Blockchain technology: Towards utopia or dystopia? In his book, Campbell-Verduyn (2018) brings scholars of anthropology, economics, science, technology and sociology together with global political economic scholars to assess the actual implications ...
Myriam Ertz, Joanie Arsenault
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Emerging models of power among South African women business leaders
SA Journal of Industrial Psychology, 2016 Orientation: This paper represents a broader study which explores how South African women business leaders construct power in their life and leadership narratives.
Lisa Kinnear, Karen Ortlepp
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Jurnal Sistem Informasi, 2016 Companies that implement information technology should have the ability to manage the governance and the implementation of the Information Technology Governance (ITG).
Amanda Yunia Zafarina +2 more
doaj +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source