Results 61 to 70 of about 720,141 (268)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Appropriate technology application of traditional clove oil production, effort to up-grade quality

Advances in Food Science, Sustainable Agriculture, and Agroindustrial Engineering, 2020
In East Java, the production of clove leaf oil refinement is developed by businesses owned by rural people. The processing operation is simple and start-up investment is low.
Musthofa Lutfi, Kusubakti Andjani, Ilhamuddin , Hamidah Nayati Utami, Firdiani Nur Afifah   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Load cell adoption in an electronic drag force flowmeter Medidor de vazão eletrônico com célula de carga

Scientia Agricola, 2011
This research introduces the development of an electronic flowmeter based on the drag force that a body experiences when immersed in a fluid stream. Its main goal was the development of an Electronic Drag Force Flowmeter (EDFF) using a load cell, as well
Antonio Pires de Camargo, Tarlei Arriel Botrel, Ricardo Godoi Vieira, Marinaldo Ferreira Pinto, Lucas Melo Vellame   +4 more
doaj   +1 more source

Innovation and transportation's technologies [PDF]

Journal of Advanced Transportation, 2000
AbstractI critique the innovation processes that yield transportation's technologies, and to aid my analysis I look back to take advantage of the accumulation of experiences and insights marked by the millennium.I identify supply, transport, and user systems.
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Paths and Countermeasures for High-Quality Development of Algae Industry Under the Background of “All-Encompassing Approach to Food” [PDF]

Progress in Fishery Sciences
Algae have important strategic significance in optimizing food supply systems, promoting carbon sink fishery development, and enhancing marine economic competitiveness owing to their efficient biosynthetic capability, rich nutritional value, and ...
GUO Yingying, YU Fan, WANG Lianzhu, LI Na, ZHU Wenjia, XU Dong, LI Jie, JIANG Yanhua, YAO Lin   +8 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source