Results 41 to 50 of about 735,543 (263)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fluorescence localization and tracking imaging with a spectral-splitting perovskite single-pixel detector

Nature Communications
Image-guided surgery systems require precise fusion of fluorescence mapping and structural background imaging, yet current dual-camera system methods suffer from field-of-view misalignment and pixel offsets, risking millimeter-scale surgical errors.
Yujin Liu, Hongling Wan, Xinyu Yin, Zhihao Zhang, Jingjing Liu, Jingyang Xing, Hao Wang, Hanyan Zhao, Jieyu Tian, Xianping He, Jiaqi Wei, Zhong Ji, Xueli Chen   +12 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Practical Bearing Failure Detection Method Using a New Efficient Deep Network With the Knowledge Self-Adaptive Evolution

Shock and Vibration
Intelligent fault diagnosis technology based on the deep neural network has shown significant advancements in recent years. However, it is difficult and expensive to deploy a fault diagnosis neural network with a huge number of parameters to an embedded ...
Mengyu Ji, Lijun Chen, Yeming Yao, Xiaoping Wang, Cheng Chang, Yunan Zhou   +5 more
doaj   +1 more source

InP photonic integrated multi-layer neural networks: Architecture and performance analysis

APL Photonics, 2022
We demonstrate the use of a wavelength converter, based on cross-gain modulation in a semiconductor optical amplifier (SOA), as a nonlinear function co-integrated within an all-optical neuron realized with SOA and wavelength-division multiplexing ...
Bin Shi, Nicola Calabretta, Ripalta Stabile   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

On-chip integrated process-programmable sub-10 nm thick molecular devices switching between photomultiplication and memristive behaviour

Nature Communications, 2022
Developing molecular electronics is challenged by integrating fragile organic molecules into modern micro/nanoelectronics based on inorganic semiconductors. Li et al.
Tianming Li, Martin Hantusch, Jiang Qu, Vineeth Kumar Bandari, Martin Knupfer, Feng Zhu, Oliver G. Schmidt   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source