Results 31 to 40 of about 1,294,318 (267)

Innovation in Retail Process: From Consumers’ Experience to Immersive Store Design

Journal of Technology Management & Innovation, 2012
Due to the current advances in Information and Communication Technologies and consumers’ increasing interest in entertaining and interactive retail environments, the sector of retailing is forced to pursuit innovation to maintain existing consumers and ...
Eleonora Pantano, Giuseppe Laria
doaj   +1 more source

Management Technology Convergence [PDF]

, 1995
Historically, much of our network management technology has been characterized by a sharp focus on local enclave management, with an unstated assumption that someone owns the entire enclave of interest, so that whatever happens outside that enclave can be seen as being Someone Else’s Problem (SEP).
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Patent management strategies: A review

Journal of Economics and Management, 2020
Aim/purpose – Intellectual property right management plays an increasingly important role in firms’ business strategies. While empirical findings prove that strategic intellectual property management is positively correlated with multiple dimensions of ...
Grzegorczyk Tomasz, Głowiński Robert
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Manufactura biológica e inteligente: atributos de la vida aplicados al desarrollo tecnológico

Ingeniería e Investigación, 2009
Los entornos altamente dinámicos caracterizados por el predominio del conocimiento como motor del desarrollo hacen que sea necesario abordar problemáticas específicas a través de enfoques multidisciplinarios.
Claudia Nelcy Jiménez Hernández, Óscar Fernando Castellanos Domínguez, Luz Alexandra Montoya Restrepo   +2 more
doaj  

Strategies to Mitigate Technoference Among Indian Youth: A Qualitative Study Using Semi-Structured Interviews

Journal of Psychiatry Spectrum
Background: The growing use of digital devices has led to the phenomenon of “technoference” – technology-induced disruptions in interpersonal communication, particularly among youth.
M. S. Neeraj, B. Parthasarathy Nirmala, N. Janardhana, Manoj Kumar Sharma   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source