Results 51 to 60 of about 5,594,926 (293)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Technology geography: a new area of scientific inquiry [PDF]

, 2003
Operations management, international management, public policy and\ud economic geography are four scientific areas, which come together in the study of\ud international technology transfer.
Bruijn, Erik J. de, Steenhuis, Harm-Jan
core   +8 more sources

Applications of space technology to water resources management [PDF]

, 1977
Space technology transfer is discussed in terms of applying visible and infrared remote sensing measurement to water resources management. Mapping and monitoring of snowcovered areas, hydrologic land use, and surface water areas are discussed, using ...
Salomonson, V. V.
core   +1 more source

Drones: Innovative Technology for Use in Precision Pest Management. [PDF]

, 2020
Arthropod pest outbreaks are unpredictable and not uniformly distributed within fields. Early outbreak detection and treatment application are inherent to effective pest management, allowing management decisions to be implemented before pests are well ...
de Lange, Elvira S, Heldens, Wieke B, Iost Filho, Fernando H, Kong, Zhaodan   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Challenges to radical innovation: A car for the future: Part one [PDF]

Megatrend Revija, 2020
The car of the future is one of the most fashionable issues in the press, in political sketches and in academia. This first article is dealing with the various available options for automotive power train: gasoline, diesel, bio-fuels, natural gas ...
Chanaron Jean-Jacques
doaj  

Translating High Hopes Into Tangible Benefits: How Incumbents in Supply Chain and Logistics Approach Blockchain

IEEE Access, 2020
Blockchain is expected to have a transformational effect on supply chain and logistics due to its promise to improve the information flow between the supply chain partners.
Niels Hackius, Moritz Petersen
doaj   +1 more source