Results 51 to 60 of about 1,305,687 (266)

Challenges to radical innovation: A car for the future: Part one [PDF]

open access: yesMegatrend Revija, 2020
The car of the future is one of the most fashionable issues in the press, in political sketches and in academia. This first article is dealing with the various available options for automotive power train: gasoline, diesel, bio-fuels, natural gas ...
Chanaron Jean-Jacques
doaj  

Translating High Hopes Into Tangible Benefits: How Incumbents in Supply Chain and Logistics Approach Blockchain

open access: yesIEEE Access, 2020
Blockchain is expected to have a transformational effect on supply chain and logistics due to its promise to improve the information flow between the supply chain partners.
Niels Hackius, Moritz Petersen
doaj   +1 more source

On the future of internet management technologies

open access: yesIEEE Communications Magazine, 2003
As the Internet continues to grow, it becomes more and more apparent that existing Internet management technologies need to be improved, extended or replaced in order to extend functionality and reduce development time and operational costs. Within the IETF, IRTF, and IAB, several new approaches are currently under discussion.
Schönwälder, Jürgen   +3 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Technology, wealth and modern management of technology [PDF]

open access: yesManaging Global Transitions, 2012
In the paper, we propose somewhat different conceptualizations of technology, of a fundamental relationship between technology and wealth in a society, of technological capability, and of management of technology. We based our proposed conceptualizations on the current general and relevant technological practice.
Slavko Dolinsek, Peter Strukelj
openaire   +1 more source

Technological Management and the Rule of Law [PDF]

open access: yesLaw, Innovation and Technology, 2016
ABSTRACTThis article is a sequel to ‘In the Year 2061: From Law to Technological Management’. Its purpose is to consider whether, and if so how, the Rule of Law together with the Fullerian principles of legality might be applied to a regulatory environment that is technologically managed rather than rule-based.
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Blockchain-Enabled Pension System Innovations: A Hungarian Case Study on Business Process Management Integration

open access: yesComputers
This paper explores the integration of Business Process Management (BPM) with blockchain technology to enhance pension systems, using Hungary as a case study.
Dániel Kovács   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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