Results 61 to 70 of about 1,305,687 (266)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Prospectiva Tecnológica como base de la Innovación en una compañía colombiana de insumos para el sector construcción

Teuken Bidikay, Revista Latinoamericana de Investigación en Organizaciones Ambiente y Sociedad, 2013
El presente artículo da a conocer el desarrollo de un estudio que tiene como objetivo proponer alternativas y herramientas para la implementación de prospectiva tecnológica en una empresa dedicada a la producción y comercialización de insumos para la ...
Erica Yaneth Guisao G., Abdul Zuluaga M., Rodrigo A. Gómez M.   +2 more
doaj  

Requirements for a systems-based research and development management process in transport infrastructure engineering

South African Journal of Industrial Engineering, 2015
The management of research and development (R&D) in the transport infrastructure field is complex due to the multidisciplinary nature of the work. The literature shows that linear R&D models that progress from idea through to consumer product are not ...
Rust, Frederik Christoffel
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Addressing Burnout among Healthcare Technology Management Professionals. [PDF]

Biomed Instrum Technol, 2023
Andiappan M, Dufour L, Senkaiahliyan S.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Medios de control para un sistema de gestión de la innovación en las empresas manufactureras: caso agroindustria

Ingeniería Industrial, 2015
El presente artículo constituye el primer avance de una investigación que pretende proponer una metodología de diagnóstico sobre un sistema integrado de gestión de la innovación (SIGI), mediante una investigación cuantitativa y cualitativa en las ...
Manuel-Fernando Montoya-Ramírez
doaj   +1 more source

Analysing the current status, hotspots, and future trends of technology management: Using the WoS and scopus database. [PDF]

Heliyon, 2023
Yubo S, Ramayah T, Hongmei L, Yifan Z, Wenhui W.   +4 more
europepmc   +1 more source