Tecnologia biomédica - Open Access .click

Results 1 to 10 of about 3,328 (89)

Relapses, Comorbidities, and Predictors of Outcome in Anti‐GABAA Receptor Encephalitis

Annals of Neurology, EarlyView.
Objectives To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti‐γ‐aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utility of LIM‐domain‐only‐protein 5 (LMO5) antibodies as tumor markers.
Claudia Papi +33 more
wiley +1 more source

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes +9 more
wiley +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda +5 more
wiley +1 more source

Frequência escolar em indivíduos com paralisia cerebral no Brasil

Developmental Medicine &Child Neurology, EarlyView.
Objetivo Identificar fatores associados à frequência escolar entre crianças, adolescentes e jovens adultos brasileiros com paralisia cerebral (PC), utilizando dados populacionais do Registro Brasileiro de Paralisia Cerebral (RBPC). Método Este estudo transversal analisou dados de 774 indivíduos com PC, com idades entre 4 e 21 anos, registrados no RPBC.
Ricardo Rodrigues de Sousa Junior +10 more
wiley +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio +38 more
wiley +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source

Effects of repeated exposure to ozonated water on hair fibre structure and integrity: Part I

International Journal of Cosmetic Science, EarlyView.
Repeated exposure to ozonated water caused cumulative oxidative changes in hair, altering structural integrity, thermal behaviour and mechanical properties. The findings reveal a distinct ozone‐induced damage profile that progresses beyond the cuticle, challenging claims of hair‐revitalizing benefits. Abstract Objective Ozone has recently been marketed
Pedro Augusto Laurindo Igreja Marrafa +5 more
wiley +1 more source

Physiological and Sleep Profiles in Insomnia, OSA and COMISA: A Comparative Study in Portugal and Spain

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia and obstructive sleep apnea (OSA) are common sleep disorders that often co‐occur as comorbid insomnia and sleep apnea (COMISA), worsening health outcomes. This study characterized and compared the physiological and sleep profiles of insomnia, OSA and COMISA in population‐based datasets from Portugal (n = 147) and Spain (n = 264 ...
Margarida Carvalho +9 more
wiley +1 more source

Systemic and Local Adiposity in the Bone Marrow Microenvironment Associated With Improved Prognosis in Hodgkin Lymphoma: Imaging and Molecular Analysis

International Journal of Cancer, Volume 159, Issue 3, Page 782-796, 1 August 2026.
Schematic overview of systemic and bone marrow‐specific adiposity in Hodgkin Lymphoma (HL). Body Mass Index was associated with bone marrow (BM) involvement, relapse, and mortality (1). In contrast, increased yellow marrow density was associated with poorer prognosis (2).
Andreia Matos +22 more
wiley +1 more source

Trace Element Analysis in Human Neuroblastoma Cell Spheroids Supplemented With ZnCl2 by Micro‐XRF

X-Ray Spectrometry, Volume 55, Issue 4, Page 545-552, July/August 2026.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhood, is responsible for ~10% of pediatric cancer deaths and has high potential for metastasis. Metals are extremely important in biological processes, and changes in their levels have been correlated with the development of cancerous growth.
J. E. P. Rosa +10 more
wiley +1 more source