Results 31 to 40 of about 1,887 (161)

Adaptive Laboratory Evolution of Staphylococcus aureus Resistance to Vancomycin and Daptomycin: Mutation Patterns and Cross-Resistance

open access: yesAntibiotics, 2023
Vancomycin and daptomycin are first-line drugs for the treatment of complicated methicillin-resistant Staphylococcus aureus (MRSA) infections, including bacteremia.
Vladimir Gostev   +9 more
doaj   +1 more source

Telavancin — New Antimicrobial Active Against Multiresistant Gram-Positive Pathogens. Clinical and Microbiological Features in Questions and Answers [PDF]

open access: yesКлиническая микробиология и антимикробная химиотерапия, 2015
Telavancin is a first marketed representative of semisinthetic lipoglycopeptides — new generation of glycopeptide antimicrobials. Telavancin is registered for the treatment of nosocomial pneumonia and skin and soft tissue infections caused by Gram ...
Dekhnich A.V.   +5 more
doaj  

Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms

open access: yesMicroorganisms, 2019
Increasing multidrug-resistance to Gram-positive pathogens, particularly to staphylococci, enterococci and streptococci, is a major problem, resulting in significant morbidity, mortality and healthcare costs. In recent years, only a small number of novel
Despoina Koulenti   +7 more
doaj   +1 more source

Intravenous (IV) cefazolin with oral probenecid: A novel daily regimen for the management of Methicillin Sensitive Staphylococcus aureus (MSSA) bacteremia in a patient with renal dysfunction

open access: yesIDCases, 2020
A 78 year old man developed a methicillin sensitive Staphylococcus aureus (MSSA) post-operative wound infection following an elective L2-L4 laminectomy.
Sunish Shah   +3 more
doaj   +1 more source

Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria

open access: yesAngewandte Chemie, Volume 137, Issue 25, June 17, 2025.
A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A overcomes vancomycin resistance and shows strong activity against drug‐resistant Gram‐positive bacteria, in particular, high‐priority pathogens such as ...
Amninder Kaur   +7 more
wiley   +2 more sources

New Antibiotics in the Therapy of Osteomyelitis [PDF]

open access: yesMediterranean Journal of Infection, Microbes and Antimicrobials, 2017
Osteomyelitis is probably the oldest known infection in the history of life. It can develop secondary to local tissue disruption, ischemia and associated chronic wounds or via hematogenous infection.
Stefanie HIRSIGER   +2 more
doaj   +1 more source

Systematic Review and Meta-Analysis of the Efficacy and Safety of Telavancin for Treatment of Infectious Disease: Are We Clearer?

open access: yesFrontiers in Pharmacology, 2016
Telavancin is approved to treat complicated skin and skin structure infections, hospital-acquired and ventilator-associated bacterial pneumonia caused by Staphylococcus aureus.
Junlan Chuan   +6 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

open access: yesAngewandte Chemie International Edition, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma   +5 more
wiley   +1 more source

Telavancin

open access: yes, 2009
: In September 2009, telavancin (Vibativ; Theravance/Astellas Pharma), a lipoglycopeptide antibiotic, was approved by the US FDA for the treatment of adult patients with complicated skin and skin structure ...
Corey, G. Ralph   +9 more
core   +1 more source

Nasopharyngeal Carriage Rate, Risk Factors, and Co‐Resistance Patterns of Methicillin‐Resistant Staphylococcus aureus in Ethiopia: Systematic Review and Meta‐Analysis

open access: yesMicrobiologyOpen, Volume 15, Issue 5, October 2026.
This systematic review and meta‐analysis show that nasopharyngeal carriage of methicillin‐resistant Staphylococcus aureus remains an important public health concern in Ethiopia. High resistance to commonly used antibiotics and significant associations with prior hospitalization and antibiotic use highlight the need for strengthened antimicrobial ...
Simachew Getaneh Endalamew   +13 more
wiley   +1 more source

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