Results 121 to 130 of about 930,586 (315)

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Old Wine in New Bottles. Narrative complexity in the dawn of Netflix Originals (2013-2017)

Communication & Society (Formerly Comunicación y Sociedad)
This article explores how the first five years of Netflix Originals dramatic storytelling fit the “Complex TV” label that Mittell defined, with its innovative season-drop delivery strategy. We focus on one narratological device: the delimited flashback,
José-Antonio Planes, Alberto-N. García
doaj   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro‐Vascularized Bone Regeneration

Advanced Science, EarlyView.
This study develops neural bioprinted piezoelectric scaffolds which construct local “sensor‐effector” circuit, inspired by the skeletal interoception system. Upon US stimulation sensing and mechanoelectrical coupling by PLLA nanofibers, the incorporated DRG neurons effect through Ca2+ influx‐induced enhanced secretion and expression of CGRP.
Yingze Su, Haomin Wang, Weixi Liu, Kangming Chen, Yiyang Min, Jinbo Zhu, Xueyang Li, Anning Su, Hao Yang, Lei Yang, Yun Ji, Yuxin Zhang, Jisi Zheng, Chi Yang, Chuanglong He, Tao Li, Shuo Chen, Tao Wu, Xiaodong Chen   +18 more
wiley   +1 more source

Dual‐Strategy Design of Heterojunction‐Enhanced Piezoelectric Hydrogels for Periodontitis Treatment

Advanced Science, EarlyView.
This study developed a piezoelectric hydrogel integrating heterojunction enhancement and dual‐salt synergy, combining robust electrical performance with mechanical stability and bioactivity to better match the periodontal microenvironment. Under ultrasound activation, the hydrogel markedly promotes macrophage M2 polarization, thereby reducing the ...
Qiangqiang Zhou, Shaojun Fang, Changyi Li, Mengqi Zhou, Xin Sui, Chen Hu, Huaxing Xu, Shiyi Yang, Bing‐Qiang Lu, Rongjun Zhang, Xiaoling Wei   +10 more
wiley   +1 more source

Moderation and mediation analyses of exposure to television violence contents and contextual features and its influence on adolescents’ aggressive behaviours / Mohammad Yaakob [PDF]

, 2012
Previous studies on the effects of exposure to television violence on viewers’ aggressive behaviours have produced mixed results. Some studies have found significant effect sizes while others have found low and non-significant effect sizes.
Yaakob, Mohammad
core  

Molecularly Bridged Heterointerface Engineering: Designing Transparent, Wear‐Resistant, Hard yet Flexible Optoelectronic Protective Film

Advanced Science, EarlyView.
A molecular‐bridging heterogeneous interface engineering strategy is introduced to combine a polyhedral oligomeric silsesquioxane (POSS)‐based hard coating with a colorless polyimide (CPI)‐based flexible layer. The robust heterogeneous interface endows the integrated system with the superior properties of both layers and their synergistic ...
Huiyang Lu, Zihui Liu, Jianan Yuan, Yunhao Wei, Shuangfei Xiang, Qinghua Lu   +5 more
wiley   +1 more source

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

Advanced Science, EarlyView.
Schematic illustration of injectable PDA‐modified GelMA microspheres loaded with BioPre‐Exos for vascularized bone regeneration. ABSTRACT Critical‐sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self‐healing capacity.
Lijun Li, Hao Zhang, Lingtong Sun, Yingfeng Su, Yang Xu, Jian Huang, Jingchao Wen, Jinjin Zhu, Jianjun Ma, Wenbin Xu   +9 more
wiley   +1 more source

Farmers' Participation in Messenger‐Based Social Groups And Its Effects on Performance in Irrigated Areas of Kazakhstan and Uzbekistan

Agribusiness, EarlyView.
ABSTRACT The penetration of information and communication technologies (ICTs) in farming communities is increasing the use of smartphone‐based instant messaging apps. Despite this, the reasons behind participation and the impact on farm productivity in developing countries remain unexplored.
Zafar Kurbanov, Abdusame Tadjiev, Nodir Djanibekov, Ajit Govind, Akmal Akramkhanov   +4 more
wiley   +1 more source