Results 301 to 310 of about 161,718 (344)
Chromosomal Instability and Telomere Attrition in Systemic Sclerosis: A Historical Perspective. [PDF]
Genes (Basel)Artlett CM.
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Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1. [PDF]
Front OncolZhou H +12 more
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Telomeres control human telomerase (<i>TERT</i>) expression through non-telomeric TRF2. [PDF]
ElifeSengupta A +18 more
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Telomerase and it's inhibition in caner: a review article
, 2009 Noori-Daloii MR, Hesami SS
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Der Hautarzt, 1997
Telomerase is an enzyme that elongates telomeric repeats, the specialized structures at the ends of chromosomes that provide genomic stability and compensate for the physiologic process of telomere shortening. It has been implicated in cellular senescence, immortalization, and carcinogenesis.
J, Lübbe, H, Nakazawa, G, Burg
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Telomerase is an enzyme that elongates telomeric repeats, the specialized structures at the ends of chromosomes that provide genomic stability and compensate for the physiologic process of telomere shortening. It has been implicated in cellular senescence, immortalization, and carcinogenesis.
J, Lübbe, H, Nakazawa, G, Burg
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Current Opinion in Structural Biology, 1999
Telomerases are RNA-dependent polymerases that catalyse the synthesis of the telomeric DNA at the tips of eukaryotic chromosomes. The recent identification of the catalytic subunit of telomerases from several different species suggests that the core of the telomerase is conserved.
M, O'Reilly, S A, Teichmann, D, Rhodes
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Telomerases are RNA-dependent polymerases that catalyse the synthesis of the telomeric DNA at the tips of eukaryotic chromosomes. The recent identification of the catalytic subunit of telomerases from several different species suggests that the core of the telomerase is conserved.
M, O'Reilly, S A, Teichmann, D, Rhodes
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Telomerase, Telomerase Inhibition, and Cancer
Journal of Anti-Aging Medicine, 2003Telomeres, located at the ends of eukaryotic chromosomes, are synthesized by the enzyme telomerase and are responsible for maintaining chromosome length. The absence of telomerase in most somatic cells has been associated with telomere shortening and aging of these cells. In contrast, high levels of telomerase activity are observed in over 90% of human
Ali, Ahmed, Trygve O, Tollefsbol
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Rejuvenation Research, 2006
Given the constitutive expression of telomerase in the majority of human tumors, telomerase inhibition is an attractive, broad-spectrum therapeutic target for cancer treatment. Therapeutic strategies for inhibiting telomerase activity have included both targeting components of telomerase (the protein component, TERT, or the RNA component, TERC) or by ...
Aisha, Siddiqa +2 more
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Given the constitutive expression of telomerase in the majority of human tumors, telomerase inhibition is an attractive, broad-spectrum therapeutic target for cancer treatment. Therapeutic strategies for inhibiting telomerase activity have included both targeting components of telomerase (the protein component, TERT, or the RNA component, TERC) or by ...
Aisha, Siddiqa +2 more
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