Results 311 to 320 of about 161,718 (344)
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Trends in Biotechnology, 2001
There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the ...
L K, White, W E, Wright, J W, Shay
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There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the ...
L K, White, W E, Wright, J W, Shay
openaire +2 more sources
Current Opinion in Structural Biology, 2011
Telomeres and their associated proteins are specialized structures at the ends of linear chromosomes that function as caps that protect the DNA from exonuclease degradation and recombination events that could lead to genomic instability. In this review, we discuss recent publications describing the high-resolution structures of individual domains and ...
Mark, Mason +2 more
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Telomeres and their associated proteins are specialized structures at the ends of linear chromosomes that function as caps that protect the DNA from exonuclease degradation and recombination events that could lead to genomic instability. In this review, we discuss recent publications describing the high-resolution structures of individual domains and ...
Mark, Mason +2 more
openaire +2 more sources
Cancer Letters, 2003
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
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The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
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Telomerase activity in human germline and embryonic tissues and cells.
Developmental Genetics, 1996Telomerase is a ribonucleoprotein that synthesizes telomere repeats onto chromosome ends and is involved in maintaining telomere length in germline tissues and in immortal and cancer cells.
W. Wright +4 more
semanticscholar +1 more source
1995
Abstract In three ciliates and two mammals it has been shown that terminal repeat sequences are synthesized by a specialized DNA polymerase called telomerase (reviewed by Greider 1990; Blackburn 1992). This chapter investigates to what extent the known properties of telomerase are consistent with various features of the terminal repeat ...
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Abstract In three ciliates and two mammals it has been shown that terminal repeat sequences are synthesized by a specialized DNA polymerase called telomerase (reviewed by Greider 1990; Blackburn 1992). This chapter investigates to what extent the known properties of telomerase are consistent with various features of the terminal repeat ...
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Gan to kagaku ryoho. Cancer & chemotherapy, 1996
Telomerase is expected to be a powerful tool for cancer diagnosis and cancer chemotherapeutics because of its selective expression exclusively in various cancer tissues at a high frequency (90%) in human somatic tissues. Some precancerous tissues also express telomerase at a high frequency. Normal somatic tissues are mostly telomerase negative.
T, Ide, H, Tahara
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Telomerase is expected to be a powerful tool for cancer diagnosis and cancer chemotherapeutics because of its selective expression exclusively in various cancer tissues at a high frequency (90%) in human somatic tissues. Some precancerous tissues also express telomerase at a high frequency. Normal somatic tissues are mostly telomerase negative.
T, Ide, H, Tahara
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Specific association of human telomerase activity with immortal cells and cancer.
Science, 1994N. Kim +9 more
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Extension of life-span by introduction of telomerase into normal human cells.
Science, 1998A. Bodnar +9 more
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Telomeres and telomerase: three decades of progress
Nature reviews genetics, 2019J. Shay, W. Wright
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