Results 141 to 150 of about 535,757 (290)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Tunable Temperature-Sensitive Transcriptional Activation Based on Lambda Repressor

Temperature is a versatile input signal for the control of engineered cellular functions. Sharp induction of gene expression with heat has been established using bacteria- and phage-derived temperature-sensitive transcriptional repressors with tunable ...
Lealia L. Xiong (12878886), Marjorie T. Buss (12878892), Mikhail G. Shapiro (2390695), Michael A. Garrett (12878889), Julia A. Kornfield (1659787)   +4 more
core   +1 more source

Magnetotransport Properties of Quasi-Free-Standing Epitaxial Graphene Bilayer on SiC: Evidence for Bernal Stacking

, 2011
We investigate the magnetotransport properties of quasi-free-standing epitaxial graphene bilayer on SiC, grown by atmospheric pressure graphitization in Ar, followed by H-2 intercalation.
T. E. Beechem, Tutuc, E., KIM, SEYOUNG, Lee, Kayoung, Beechem, T. E., Kayoung Lee, Seyoung Kim, Ohta, Taisuke, M. S. Points, Taisuke Ohta, E. Tutuc, Points, M. S.   +11 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Temperature-sensitive alleles of cdc45 accumulate cells with G1 DNA content at the restrictive temperature.

, 2019
(Top) Experimental scheme; asynchronous cultures of the indicated cdc45 mutants were grown at 25°C in YPD and shifted to 37°C for 4h. (Bottom) Samples collected at indicated time points were analyzed using flow cytometry to assess their DNA content.
Ramon Y. Rios-Morales (6508808), Stephen P. Bell (164403), Sze Ham Chan (246350)   +2 more
core   +1 more source

Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo

Nature Communications
Nanothermometers enable the detection of temperature changes at the microscopic scale, which is crucial for elucidating biological mechanisms and guiding treatment strategies.
Yukai Wu, Fang Li, Yanan Wu, Hao Wang, Liangtao Gu, Jieying Zhang, Yukun Qi, Lingkai Meng, Na Kong, Yingjie Chai, Qian Hu, Zhenyu Xing, Wuwei Ren, Fuyou Li, Xingjun Zhu   +14 more
doaj   +1 more source

Parametric study and thermal sensitivity analysis of a triple effect absorption refrigeration system

Case Studies in Thermal Engineering
Absorption refrigeration systems represent an efficient means of cooling utilizing waste heat, with triple-effect absorption refrigeration systems outperforming their double and single-effect counterparts in terms of efficiency.
Kenan Saka, Mehmet Fatih Orhan
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Sun-perturbed dynamics of a particle in the vicinity of the Earth-Moon triangular libration points

, 2008
textThis study focuses on the Sun's influence on the motion near the triangular libration points of the Earth-Moon system. It is known that there exists a very strong resonant perturbation near those points that produces large deviations from the ...
Munoz, Jean-Philippe
core  

Monitoring food quality using sensor technology from harvest to home [PDF]

, 2005
A food quality sensor is a device that responds to some property associated with food quality and transforms the response into a signal (1). This signal may provide direct information about the quality factor to be measured or may have a known ...
Frisby, June
core