Results 111 to 120 of about 1,217,593 (303)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Sensitivity and specificity of axillary temperature measurement in fever diagnosis
Payesh, 2003 Objective(s): To investigate on accuracy of axillary temperature measurement. Material & Methods: A total of 400 individuals with or without fever attending the Shariati Hospital in Tehran were entered into the study.
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doaj
Biochemical and Biophysical Research Communications, 2018 The actin cytoskeleton is modulated by regulatory actin-binding proteins which fine-tune the dynamic properties of the actin polymer to regulate function. One such actin-binding protein is tropomyosin (Tpm), a highly-conserved alpha-helical dimer which stabilises actin and regulates interactions with other proteins. Temperature sensitive mutants of Tpm
Chloe A. Johnson +12 more
openaire +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Tipping elements and climate-economic shocks: Pathways toward integrated assessment
, 2016 The literature on the costs of climate change often draws a link between climatic 'tipping points' and large economic shocks, frequently called 'catastrophes'. The use of the phrase 'tipping points' in this context can be misleading.
Kopp, Robert E. +3 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Dynamic Characteristics of Warm Mix Foamed Asphalt Mixture in Seasonal Frozen Area
Advances in Materials Science and Engineering, 2019 In order to study dynamic characteristics of warm mix foamed asphalt mixture in seasonal frozen area, cylinder dynamic modulus test of four kinds of mixture with two gradations and three kinds of asphalt was carried out by UTM-100.
Yun Hou +4 more
doaj +1 more source
Carbon thin film thermometry [PDF]
The work concerning carbon thin film thermometry is reported. Optimum film deposition parameters were sought on an empirical basis for maximum stability of the films.
Collier, R. S. +2 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Research on Machine Tool Thermal Error Compensation Based on an Optimized LSTM Model
ActuatorsThermal error is a significant factor affecting the machining accuracy of machine tools, and error compensation is an economical and effective method to improve machine tool accuracy.
Xiangrui Zhao +3 more
doaj +1 more source