Results 71 to 80 of about 11,039,660 (346)

The Temperature Scale [PDF]

open access: yesNature, 1964
I BELIEVE Mr. Le Fevre's objections are due to the long-term habits of considering temperature measured by a degree (centigrade, Celsius, Kelvin, Fahrenheit, Rankine, etc.); hence, he feels it is necessary that the temperature should have some type of unit name. There is, of course, nothing wrong with this since, for example, we call the unit of energy,
openaire   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Doping a Mott insulator: Physics of high-temperature superconductivity [PDF]

open access: yes, 2004
This article reviews the physics of high-temperature superconductors from the point of view of the doping of a Mott insulator. The basic electronic structure of cuprates is reviewed, emphasizing the physics of strong correlation and establishing the ...
P. Lee, N. Nagaosa, X. Wen
semanticscholar   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Fractionation of nitrogen isotopes in the enzymatic deamination of alanine: an insight into the quantitative evaluation of anaerobic metabolism in ecosystems

open access: yesProgress in Earth and Planetary Science
Nitrogen isotope ratios of amino acids have been employed as a tool for illustrating the resource utilization of organisms and the trophic transfer between organisms in food webs.
Yuko Takizawa   +6 more
doaj   +1 more source

Single-molecule strong coupling at room temperature in plasmonic nanocavities

open access: yesNature, 2016
Photon emitters placed in an optical cavity experience an environment that changes how they are coupled to the surrounding light field. In the weak-coupling regime, the extraction of light from the emitter is enhanced.
R. Chikkaraddy   +9 more
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Temperature of the Breath [PDF]

open access: yesNature, 1880
THERE is no doubt that Dr. Roberts has discovered the true explanation of the phenomena that puzzled me and a good many others to whom I showed them. I have repeated Dr. Roberts's method of heating the enveloping material so as to expel all moisture from it, cooling it down to the temperature of the room and then breathing through it.
openaire   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

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