Results 81 to 90 of about 5,090,074 (298)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Meridional distribution and seasonal variation of stable oxygen isotope ratio of precipitation in the Southern Ocean

open access: yesAntarctic Record, 2010
The stable oxygen isotope ratio(δ^O) in precipitation is known to have important meridional and seasonal variations, but there are almost no measurements of δ^O in precipitation over polar oceans.
Kayo Nakamura   +3 more
doaj   +1 more source

Enhanced expression of genes in the brains of larvae of Mamestra brassicae (Lepidoptera: Noctuidae) exposed to short daylength or fed Dopa

open access: yesEuropean Journal of Entomology, 2003
The cabbage armyworm, Mamestra brassicae, enters diapause in the early pupal stage. Pupal diapause is induced by rearing the larvae under short day lengths.
Masahide URYU   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Low-Temperature Physics [PDF]

open access: yesNature, 1948
THE great attraction of low temperature physics as a field of research is that so many of the phenomena still lack any fundamental theory, so that the outcome of any new experiment is rarely a foregone conclusion. The outstanding phenomena at present requiring something deeper than ‘phenomen-ologica theories are superconductivity and the properties of ...
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Low-temperature corrosion in large-scale biomass boilers

open access: yesnpj Materials Degradation
The shift toward biomass fuels for heat and power generation has introduced a range of new challenges for power plant technology, in particular large-scale boilers.
Farzad Jafarihonar   +3 more
doaj   +1 more source

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