Results 51 to 60 of about 1,569,854 (267)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Mathematical Model of Energy Transformation Processes in Barrel System for Determining Shooting Performance

Energy Engineering and Control Systems, 2022
A phenomenon has been singled out that is present during almost every shot. It manifests itself in a muzzle blast in the form of soot of a certain amount.
Oleksandr Brunetkin, Vitalii Kuzmenko, Olha Soloviova   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Experimental and Numerical Investigation of Heat Transfer Performance for All Water Inlet and Outlet Configurations in a Panel Radiator

Buildings
In a modern-day household, the most significant part of energy consumption is space heating. In this study, the effects of connection configurations on the heat transfer from the radiator are investigated.
Ogan Karabaş, Murat Can Önen, Kadri Süleyman Yiğit   +2 more
doaj   +1 more source

Transient thermal models of induction machines under Inter‐turn short‐circuit fault conditions

IET Electric Power Applications, 2023
Induction machines are the working horses in a lot of industries. Inter‐turn short‐circuit (ITSC) fault is one of the most common failure modes taking place in them. It can generate large fault currents that lead to a local temperature rise in the faulty
An Zhao, Giovanni Zanuso, Luca Peretti
doaj   +1 more source

Numerical Investigation of the Effects of the Beam Scanning Pattern and Overlap on the Temperature Distribution during the Laser Dopant Activation Anneal Process

Applied Sciences, 2021
Laser thermal annealing (LTA) has played an important role in the fabrication of scaled semiconductor devices by reducing the heat budget of the dopant activation process.
Donghyeok Choi, Joonghan Shin
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Temperature Distribution in Core and Winding of a Transformer and Its Effect on Performance

Wasit Journal of Engineering Sciences, 2016
In order to reach the maximum power from a transformer and avoid thermal accidents, it is essential to carefully study its thermal behavior. This research is to apply some computational and analytical approaches in order to obtain a temperature ...
Mahmmod Aziz Muhammed, Abdul Ridha Ghedayer   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source