Results 71 to 80 of about 1,569,854 (267)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Energy Conversion Characteristics and Temperature Field Simulation of Ignition Resistors for Industrial Electronic Detonators

Gaoya wuli xuebao
In order to study the dynamic changes of temperature during the ignition process of the ignition resistor and solve the matching problem of the energy storage capacitor-ignition resistor system, this study measures the voltage-current changes and ...
Hongwei LI, Liguo ZHANG, En ZHOU, Hao LIANG, Lin YANG, Wanlong ZHANG   +5 more
doaj   +1 more source

Evaporator for thermal deposition of materials in vacuum

Технологія та конструювання в електронній апаратурі, 2008
The design of an evaporator intended for material deposition in vacuum-coating systems is considered, which has been successfully employed in the technological process of fabricating gallium arsenide transistors, diodes, and monolithic circuits.
V. I. Bosyi, V. P. Kokhan, N. M. Rakhmanov   +2 more
doaj  

Experimental Study of Pouch-Type Battery Cell Thermal Characteristics Operated at High C-Rates

Batteries
This paper investigates pouch-type lithium-ion battery cells with a nominal voltage of 3.7 V and a nominal capacity of 57 Ah. A numerical model of the cell was developed and implemented using the NTGK method, which accurately predicts electrochemical and
Marius Vasylius, Deivydas Šapalas, Benas Dumbrauskas, Valentinas Kartašovas, Audrius Senulis, Artūras Tadžijevas, Pranas Mažeika, Rimantas Didžiokas, Ernestas Šimkutis, Lukas Januta   +9 more
doaj   +1 more source

MODELING OF TEMPERATURE DISTRIBUTION IN BIOTISSUES

IJASOS- International E-journal of Advances in Social Sciences, 2019
One of the widely used ways to model the spread of laser beams in biological tissues is through the Monte Carlo method. This article focuses on the distribution of temperature in human skin based on the results of the Monte Carlo method for a laser beam with а wavelength of 800 .
openaire   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Thermal-breaking characteristics and crack distribution of rock irradiated by laser beams

Yantu gongcheng xuebao
The laser-assisted rock breaking is a non-contact technology employed for the rock fragmentation, with its efficiency contingent upon the laser power, irradiation time and defocusing distance. To explore the effects of various irradiation parameters, the
WANG Yijiang 1, 2, 3, YU Dongxu 1, SUN Lipeng 1, ZHU Qiyin 2, 3, WANG Jianzhou 2, 3
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source