Results 31 to 40 of about 1,270,960 (266)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Study on a Dynamic Model and Calculation Method of Wellbore Temperature in Ultra-Deep Wells

Energies
With growing global energy demand, deep and ultra-deep wells have become a focal point in oil and gas development. Wellbore temperature variations significantly impact drilling and completion operations in such wells.
Jianguo Zhao, Han Zhang, Yang Wang, Xinfeng Liu, Pingan Wang   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

CFD-modeling of the temperature field of the radiator casing of the transmitting module of the active phased antenna arrays with air cooling

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2019
Frequency multipliers are used in electronic devices to generate spectrally pure sinusoidal signals in the frequency range from a few to tens of GHz. The multipliers are used to multiply the frequency of highly stable but more low-frequency devices with ...
Yu. Nikolaenko, O. Baranyuk, S. Reva, V. Rohachov   +3 more
doaj   +1 more source

Experimental Study of the Space–Time Effect of a Double-Pipe Frozen Curtain Formation with Different Groundwater Velocities

Energies, 2021
Groundwater velocity has significant effects on the formation of a frozen curtain during freezing. In order to study the influence of the velocity on a frozen curtain, a large physical model test platform was established for double-pipe freezing.
Shicheng Sun, Chuanxin Rong, Hua Cheng, Bin Wang, Xiaogang Jiang, Wei Zhang, Yunusa Halliru   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Electromagnetic-thermal multi-physics coupling simulation of cable joints: considering contact resistance and typical defects

Frontiers in Energy Research
As the “artery” of the urban power grid, high-voltage cables and their operating status are directly related to grid safety. Cable joint is a weak part of cable line prone to defects, leading to cable failure and jeopardizing the power supply reliability.
Lifang Wu, Qingren Jin, Xiaoyong Yu, Biyun Zhang   +3 more
doaj   +1 more source

Heat-Flow Coupling Law for Freezing a Pipe Reinforcement with Varying Curvatures

Applied Sciences, 2023
Using the temperature and seepage field-coupling module within COMSOL Multiphysics software, we examined freezing behavior and its evolving patterns in curved underground freezing pipes.
Kun Yang, Jun Hu, Tao Wang
doaj   +1 more source