Results 81 to 90 of about 4,158,282 (292)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

High Magnetic Field Behaviour of the Triangular Lattice Antiferromagnet, CuFeO_2

, 2000
The high magnetic field behaviour of the triangular lattice antiferromagnet CuFeO_2 is studied using single crystal neutron diffraction measurements in a field of up to 14.5 T and also by magnetisation measurements in a field of up to 12 T.
A. Hoser, A.G. Abanov, B. D. Gaulin, D. Gignoux, D. McK. Paul, G. Balakrishnan, I.A. Zaliznyak, K. Takeda, M. Mekata, M. Mekata, M. R. Lees, M.F. Collins, O. A. Petrenko, P. Santini, S. Mitsuda, S. Mitsuda, S. Mitsuda, S.I. Abarzhi, T. Fukuda, T.-R. Zhao, T.-R. Zhao, V.R. Galakhov, Y. Ajiro, Y. Ajiro   +23 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Magnetic catalysis in hot and dense quark matter and quantum fluctuations

, 2012
We analyze chiral symmetry breaking in quark matter in an external magnetic field at zero and finite temperature and quark chemical potential. We first give a brief overview of analytic results within the mean-field approximation.
Fukushima, Kenji, Pawlowski, Jan M.
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Implementation of a Digital Model of Thermal Characteristics Based on the Temperature Field

Advanced Engineering Research
Introduction. Computer modeling allows engineers to make valid design decisions by accurately assessing the thermal characteristics of design objects. The implementation of digital twin technology in the process of designing technical facilities is the ...
V. V. Pozevalkin, A. N. Polyakov
doaj   +1 more source

Giant magnetic-field changes in radio-frequency absorption in La$_{0.67}$Sr$_{0.33}$MnO$_3$ near the Curie temperature

, 2004
The DC transport properties of and the radio-frequency (RF) wave absorption (at 2.525 MHz) in a sample of La$_{0.67}$Sr$_{0.33}$MnO$_{3}$ prepared by floating-zone method are measured. The Curie temperature, $T_{c}$, of the sample is about 374 K.
A.S. Panfilov, A.Ya. Kirichenko, B.I. Belevtsev, Belevtsev, Belevtsev, Coey, Dagotto, E.Yu. Beliayev, Eremenko, G.V. Golubnichaya, Hu, Hu, I.G. Maximchuk, J. Fink-Finowicki, Knobel, Mukhin, N.T. Cherpak, Smit, Urushibara, Vonsovsky, Wang, Wang, Zhang   +22 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Thermal Properties of Heavy Fermion Compound YbP

, 2002
Low-temperature specific heat and its field-dependence up to 16 T was measured in a stoichiometric single crystal of YbP. A sharp peak was observed at {\it T}$_{\rm N}$ = 0.53 K in zero magnetic field.
Dönni A., Dönni A., Dönni A., Harima H., Hasegawa A., Hashi K., Kasuya T., Kasuya T., Keller L., Kohgi M., Kohgi M., Le Bras G., Li D. X., Li D. X., Ohoyama K., Ohyama K., Ott H. R., Oyamada A., Oyamada A., Rossat-Mignod J., Sakon T., Takagi S., Takeda N., Ueda K.   +23 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source