Results 61 to 70 of about 11,755,516 (235)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Hospitalization of Field Museum
, 1918 Memorandum specification completed by the architectural firm Graham, Anderson, Probst and White for the trustees of the Field Museum. The specification was developed to outline the construction and finishing work for converting the existing ...
Graham, Anderson, Probst and White
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Implementation of a Digital Model of Thermal Characteristics Based on the Temperature Field
Advanced Engineering ResearchIntroduction. Computer modeling allows engineers to make valid design decisions by accurately assessing the thermal characteristics of design objects. The implementation of digital twin technology in the process of designing technical facilities is the ...
V. V. Pozevalkin, A. N. Polyakov
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The Use Of Multifrequency Induction Heating For Temperature Distribution Control
Archives of Metallurgy and Materials, 2015 The paper presents possibilities of controlling temperature field distribution in inductively heated charge. The change of its distribution was obtained using the sequential one-, two-, and three-frequency heating.
Smalcerz A.
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Study on Infiltration Through Doorway of Cold Store based on Unsteady RANS Model
Zhileng xuebao, 2017 Because the total gross of cold stores is increasing, the energy consumption of cold stores is attracting increasing attention. Infiltration through the doorway, which accounts for a large part of the total heat load, has become an important research ...
Tian Shen +3 more
doaj
Temperature Field of Tool Engaged Cutting Zone for Milling of Titanium Alloy with Ball-End Milling
Micromachines, 2018 When milling titanium alloy, the cutting temperature has a strong impact on the degree of tool wear and, in turn, tool life and the surface quality of the workpiece.
Shucai Yang +4 more
doaj +1 more source