Results 71 to 80 of about 11,755,516 (235)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Zhileng xuebao, 2019 The velocity field in the area of heat and mass transfer in a drying chamber of heat pump was investigated experimentally and an optimal configuration was determined.
Cai Dandan +4 more
doaj
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Zhileng xuebao, 2015 In this paper, the temperature uniformity of a self-designed novel multi-temperature thermostat with three chambers was studied. A steady-state three-dimensional numerical model based on one chamber ofthe thermostat was built to simulate its temperature ...
Zhao Xiuhong, Liu Baolin
doaj
Predicting daily soil temperature profiles in arable soils in cold temperate regions from air temperature and leaf area index [PDF]
, 2009 Modelling of ecosystem processes often requires soil temperature as a driving variable. Since soil temperature measurements are seldom available for regional applications, they have to be estimated from standard meteorological data. The objective of this
Kätterer, Thomas, Andrén, Olof
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
CrystalsIn order to apply laser cladding technology to the complex surface processing of hot-working dies, this study developed a numerical model for curved surface laser cladding along various scanning trajectories under multi-physics coupling considering the ...
Chenyun Deng, Wei Chen, Yingxia Zhu
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Archives of Acoustics, 2014 The aim of this work is twofold. Firstly, to verify a theoretical model which is capable of predicting temperature fields appearing in soft tissues during their ultrasound treatment.
Barbara GAMBIN +4 more
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