Results 41 to 50 of about 1,799,197 (305)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Mean Temperature Profiles in Turbulent Thermal Convection

, 2017
To predict the mean temperature profiles in turbulent thermal convection, the thermal boundary layer (BL) equation including the effects of fluctuations has to be solved. In Shishkina et al., Phys. Rev. Lett.
Ching, Emily S. C., Emran, Mohammad S., Horn, Susanne, Shishkina, Olga   +3 more
core   +1 more source

Optimization of Time-Varying Temperature Profiles for Enhanced Beer Fermentation by Evolutive Algorithms

Fermentation
Beer is one of the most popular alcoholic beverages globally, leading to continuous efforts to enhance its production methods. Raw materials and the production process are crucial in the brewing industry, with fermentation being a vital stage that ...
Pablo Ruarte, Nadia Pantano, Marianela Noriega, Cecilia Fernández, Emanuel Serrano, Gustavo Scaglia   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Stabilization of nonlinear velocity profiles in athermal systems undergoing planar shear flow

, 2005
We perform molecular dynamics simulations of model granular systems undergoing boundary-driven planar shear flow in two spatial dimensions with the goal of developing a more complete understanding of how dense particulate systems respond to applied shear.
Corey S. O’Hern, J. P. Hansen, J. T. Jenkins, Lou Kondic, Ning Xu, W. H. Press   +5 more
core   +1 more source

A Sensor to Monitor Soil Moisture, Salinity, and Temperature Profiles for Wireless Networks

Journal of Sensor and Actuator Networks
This article presents a wireless in situ sensor designed to continuously monitor profiles of parameters in porous media, such as soil moisture, salinity, and temperature.
Xavier Chavanne, Jean-Pierre Frangi
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Adaptive neuro-fuzzy inference system for temperature and humidity profile retrieval from microwave radiometer observations [PDF]

Atmospheric Measurement Techniques, 2015
The retrieval of accurate profiles of temperature and water vapour is important for the study of atmospheric convection. Recent development in computational techniques motivated us to use adaptive techniques in the retrieval algorithms.
K. Ramesh, A. P. Kesarkar, J. Bhate, M. Venkat Ratnam, A. Jayaraman   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Could multiple voids explain the Cosmic Microwave Background Cold Spot anomaly? [PDF]

, 2016
Understanding the observed Cold Spot (CS) (temperature of ~ -150 mu K at its centre) on the Cosmic Microwave Background (CMB) is an outstanding problem. Explanations vary from assuming it is just a > 3 sigma primordial Gaussian fluctuation to the imprint
Benoit-Lévy, Aurélien, Lahav, Ofer, Naidoo, Krishna   +2 more
core   +4 more sources