Results 81 to 90 of about 1,782,060 (305)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Galaxy Clusters at the Edge: Temperature, Entropy, and Gas Dynamics at the Virial Radius

, 2010
Recently, Suzaku has produced temperature and entropy profiles, along with profiles of gas density, gas fraction, and mass, for multiple galaxy clusters out to ~r_200 (~= virial radius).
Burns, Jack O., O'Shea, Brian W., Skillman, Samuel W.   +2 more
core   +1 more source

Unifying the low-temperature photoluminescence spectra of carbon nanotubes: the role of acoustic phonon confinement [PDF]

, 2014
At low temperature the photoluminescence of single-wall carbon nanotubes show a large variety of spectral profiles ranging from ultra narrow lines in suspended nanotubes to broad and asymmetrical line-shapes that puzzle the current interpretation in ...
Cassabois, Guillaume, Chassagneux, Yannick, Diederichs, Carole, Ferreira, Robson, Lauret, Jean-Sébastien, Roquelet, Cyrielle, Roussignol, Philippe, Vialla, Fabien, Voisin, Christophe   +8 more
core   +3 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Experimental Study on the Reaction of Magnesium in Carbon Dioxide and Nitrogen Atmosphere

ChemEngineering
This manuscript presents an experimental study focusing on the combustion of magnesium in an atmosphere depleted of oxygen. The study explores various mixtures of carbon dioxide and nitrogen, examining their impact on the combustion performance.
Ioan Barabulica, Marius Sebastian Secula, Adriana Mariana Asoltanei, Eugenia Teodora Iacob-Tudose, Gabriela Lisa, Ioan Mamaliga   +5 more
doaj   +1 more source

Probing the Astrophysics of Cluster Outskirts [PDF]

, 2010
In galaxy clusters the entropy distribution of the IntraCluster Plasma modulates the latter's equilibrium within the Dark Matter gravitational wells, as rendered by our Supermodel.
A. Cavaliere, A. Lapi, Broadhurst, Cavagnolo, Cavaliere, Cavaliere, Diemand, Dunkley, Fusco-Femiano, George, Hoshino, Kawaharada, Lapi, Lapi, Lapi, Lu, Mahdavi, Markevitch, McCarthy, McNamara, Meneghetti, Molendi, Nagai, Navarro, Piffaretti, Pratt, R. Fusco-Femiano, Reiprich, Riemer-Sørensen, Roncarelli, Rossetti, Snowden, Tozzi, Valageas, Vass, Vikhlinin, Voit, Voit, Wu, Zhang, Zhao   +40 more
core   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Temperature profiles of impacts [PDF]

, 1997
Similarity solutions determine the profiles of density and temperature from impacts, which determine the scaling of the temperature and optical depth on material parameters, time, screening, and impactor size. This note uses scaling results derived earlier for the growth, size, and temperature produced by impacts to discuss the radial temperature ...
openaire   +2 more sources

Effect of Gravity and Confinement on Phase Equilibria: A Density Matrix Renormalization Approach

, 1997
The phase diagram of the 2D Ising model confined between two infinite walls and subject to opposing surface fields and to a bulk "gravitational" field is calculated by means of density matrix renormalization methods.
A. Maciołek, A. O. Parry, A. O. Parry, Andrzej Drzewiński, D. B. Abraham, D. M. Kroll, E. V. Albano, E. V. Albano, Enrico Carlon, H. Au-Yang, H. Nakanishi, J. M. J. van Leeuwen, J. Rogiers, K. Binder, K. Binder, M. E. Fisher, M. E. Fisher, S. R. White, S. R. White, T. Kerle, T. Nishino   +20 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source