Results 31 to 40 of about 658,124 (263)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the critical mass of greenhouse gas
Геофизический журнал, 2018 In recent years, changes in the Earth’s climate have raised concern all around the globe. Climatologists have been drawing connections between global warming and a growing number of natural disasters, unexpected temperature fluctuations in some regions ...
E. F. Klimchuk, V. F. Tarasov
doaj +1 more source
Endodontology, 2022 Aim: This study aimed to evaluate the heat transfer to periodontal tissues and stress distribution within simulated roots with internal root resorption cavities at three different levels using two thermoplasticized obturation systems using finite element
Vibha Rahul Hegde +2 more
doaj +1 more source
On the Temperature Rise of Rubbing Surfaces.
Transactions of the Japan Society of Mechanical Engineers, 1944 摩擦面の温度が摩擦金属自体の平均温度に較べて遥かに高い値を示すだらうといふことは容易に推定されるのであるが、最近に到って潤滑作用が、麿汎な意味における一つの冷却作用と理解されるに及んで、この表面温度の特性に関する問題が愈よ大きな意味を加えてきた様に思ふ。それは冷却といふ言葉の内容が2様の意味をもつからである。即ち一つは発生熱量を出来るだけ大量に奪ふといふことで、他の一つは摩擦面の温度を出来るだけ低下させるといふことである。そしてこの冷却の結局の目的が後着にあることは無論で、ここにの問題の実用即な意味が存在する。この問題は既にバウデン等によって、特に乾燥面に関してその研究の結果が発表されてゐるのであるが、その結果に対して、.とかくの論もある様であり ...
openaire +2 more sources
Stability of peatland carbon to rising temperatures [PDF]
Nature Communications, 2016 AbstractPeatlands contain one-third of soil carbon (C), mostly buried in deep, saturated anoxic zones (catotelm). The response of catotelm C to climate forcing is uncertain, because prior experiments have focused on surface warming. We show that deep peat heating of a 2 m-thick peat column results in an exponential increase in CH4 emissions.
Wilson, R. M. +17 more
openaire +4 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Jixie chuandong, 2019 Based on the thermodynamics and dynamics analysis of polymer composite gear meshing transmission process, the coupling thermal-mechanical model is established, the changing rule of the gear body temperature rise and the transient temperature of friction ...
Tianfeng Miao +3 more
doaj
IEEE Access, 2021 Loss and temperature increase due to DC bias occurring in power transformers may lead to damage and reduced lifespan. To study the influence of different levels of DC bias on the temperature rise in transformer structural components, 0, 8, and 16 A DC ...
Mingyang Li +4 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source