Results 51 to 60 of about 703,170 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Säker storskalig vätgasbunkring - Test och validering
Safe large scale hydrogen bunkering - Test and validation The project investigates the use of green hydrogen as a sustainable fuel for shipping. It focuses on developing and validating a new cylinder design with built-in cooling to handle temperature ...
Engberg, David +6 more
core +3 more sources
Risks with hydrogen in underground facilities
, 2023 RISE has previously studied alternative fuels, such as batteries and gaseous fuels including liquid and compressed hydrogen (GH2). Each fuel has its unique risks.
Gehandler, Jonatan
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the Temperature Rise of Rubbing Surfaces.
Transactions of the Japan Society of Mechanical Engineers, 1944 摩擦面の温度が摩擦金属自体の平均温度に較べて遥かに高い値を示すだらうといふことは容易に推定されるのであるが、最近に到って潤滑作用が、麿汎な意味における一つの冷却作用と理解されるに及んで、この表面温度の特性に関する問題が愈よ大きな意味を加えてきた様に思ふ。それは冷却といふ言葉の内容が2様の意味をもつからである。即ち一つは発生熱量を出来るだけ大量に奪ふといふことで、他の一つは摩擦面の温度を出来るだけ低下させるといふことである。そしてこの冷却の結局の目的が後着にあることは無論で、ここにの問題の実用即な意味が存在する。この問題は既にバウデン等によって、特に乾燥面に関してその研究の結果が発表されてゐるのであるが、その結果に対して、.とかくの論もある様であり ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
For emitters & electronics the temperature is rising
III-Vs Review, 1996 AbstractWelcome to our penultimate issue for 1996. We have a varied collection of features this time along with a continuation of the more familiar. Amongst these we devote special attention to IC processing in celebration of one of the most popular Autumn meetings, the IEEE GaAs IC Symposium.
openaire +1 more source
Sudden Rises of Temperature [PDF]
Nature, 1890 IN NATURE, vol. xli. p. 550, it is stated that sudden rises of temperature of large amount in Great Britain “are more frequent and more extensive in amount than sudden falls—the reverse to what obtains in India.” There appears to be a somewhat similar condition of affairs in North America. Extremely sudden and large rises of temperature attend the warm
openaire +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
, 2021 The International Maritime Organization, through its correspondence group on fire safety, has underlined the need for more scientific studies regarding the performance of A-60 boundaries in case of a ro-ro space fire, especially to prevent fire spread to
Mindykowski, Pierrick
core