Results 71 to 80 of about 703,170 (308)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Thermal-Tribological Synergy in PTFE-Based Self-Lubricating Retainers for Ball Bearings Under Oil-Depleted Conditions

Lubricants
To investigate the temperature rise characteristics and tribological performance of angular contact ball bearings equipped with polymer-based self-lubricating retainers under oil-depleted conditions.
Zhining Jia, Caizhe Hao
doaj   +1 more source

Model scale tunnel fire tests on maximum ceiling gas temperature for structural protection

, 2018
Model scale tests with varying materials as tunnel structure were carried out to further study the theoretical model of maximum gas temperature for structural protection. New correlation for calculation of air mass flow rate is introduced.
Ingason, Haukur, Li, Ying Zhen
core  

Limiting flame spread rates in large compartments with visible timber ceilings

, 2023
The number of tall buildings combining both a visible mass timber structure and large open floor plans is growing rapidly introducing new fire safety challenges.
van Mierlo, Rudolf, Shettihalli Anandreddy, Vikas, Li, Tian, Sjöström, Johan, Brandon, Daniel, Just, Alar, Robijn-Meijers, Patries   +6 more
core  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Geophysical study of the epicentral area of the Katav-Ivanovsk earthquake (05.09.2018, M5.8)

Литосфера, 2020
Resarch subject. To investigate the epicentral area of the Katav-Ivanovsk earthquake (05.09.2018, M5.8), which has so far been the strongest seismic event in the Urals during the entire period of instrumental observations.
A. V. Ovcharenko, V. A. Davydov, V. A. Shchapov, A. K. Yurkov   +3 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Climate Changes Can Restore Allopatry Between Two Congeneric Birds in the Atlantic Forest

Birds
The climate is expected to change substantially by the end of the current century. In response to climate change, species may disperse, adapt, or become locally extinct.
Vitor Araujo-Lima, Rayane dos Santos Oliveira, Marcio Mageski, Rodrigo Barbosa Ferreira, Charles Duca   +4 more
doaj   +1 more source

Why Do Leaves Rise with the Temperature? [PDF]

Plant Physiology, 2019
Tropic movement in plants (movement in relation to a directional stimulus) has fascinated thinkers since ancient times (for review, see Whippo and Hangarter, 2006). This interest has led us to a good molecular understanding of how, for example, plants direct their shoots toward light and their roots toward water.
openaire   +3 more sources