Results 151 to 160 of about 12,423,355 (348)

Thermal Evaluation of the Initial Concept 3.X Vehicle at Mach 7

Energies
High-speed global surface temperature distributions and heat flux measurements on the Initial Concept 3.X vehicle (IC3X) model were investigated at the UTSA Mach 7 wind tunnel, examining angles of attack of 0° and 5° at a freestream unit Reynolds number (
Abinayaa Dhanagopal, Nathan S. Strasser, Angelina Andrade, Kevin R. Posladek, Eugene N. A. Hoffman, Christopher S. Combs   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Causal hybrid modeling with double machine learning—applications in carbon flux modeling

Machine Learning: Science and Technology
Hybrid modeling integrates machine learning with scientific knowledge to enhance interpretability, generalization, and adherence to natural laws. Nevertheless, equifinality and regularization biases pose challenges in hybrid modeling to achieve these ...
Kai-Hendrik Cohrs, Gherardo Varando, Nuno Carvalhais, Markus Reichstein, Gustau Camps-Valls   +4 more
doaj   +1 more source

Evaluation and application of low damage guar gum fracturing fluid in deep coalbed methane reservoirs

Meikuang Anquan
An evaluation of low damage guar gum fracturing fluid system based on deep coalbed methane reservoir stimulation was carried out, its on-site application research was conducted.
Yongcheng ZHANG, Liangliang LIU, Dehui LI, Yang BAI, Wei ZHANG, Yuxia QIN   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Drivers of soil heterotrophic respiration in tropical peatlands: a review to inform peat carbon accumulation modelling

Frontiers in Geochemistry
Globally peatlands store 25% of global soil organic carbon but this large carbon store is at risk under climate change and from widespread anthropogenic disturbances.
Elise M. Dehaen, Eleanor J. Burke, Sarah E. Chadburn, Jörg Kaduk, Stephen Sitch, Noah D. Smith, Angela V. Gallego-Sala   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Temperature sensitivity of Eppley broadband radiometers [PDF]

Broadband radiometers manufactured by Eppley Laboratories Inc. are commonly used to measure irradiance from both ground-based and aircraft platforms. Namely, the pyranometer (Model PSP) measures irradiance in the .3 to 3.0 micron spectral region while ...
Cox, Stephen K., Smith, William L., Jr.
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source