Results 141 to 150 of about 16,749,992 (355)

Predation life history responses to increased temperature variability [PDF]

, 2014
This study was funded by a Postdoctoral fellowship to MB (SFRH/BPD/82259/2011) Fundacao para a Ciencia e Tecnologia (www.fct.pt/index.phtml.pt) and with a ‘‘Bolsista CAPES/BRASIL’’, (Project A058/2013) to AMVMS.The evolution of life history traits is ...
Barbosa, Miguel, Miguel Barbosa (633512), Pestana, Joao, Joao Pestana (633513), Miguel Barbosa, Amadeu M. V. M. Soares (324654), Soares, Amadeu M V M, Joao Pestana, Amadeu M. V. M. Soares, Soares, Amadeu M. V. M., Amadeu M V M Soares   +10 more
core   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Heatwaves Suppress Isoprene Emission Optima in Subtropical Eucalyptus: Implications for Biogenic VOC Modeling Under Extreme Thermal Events

Geophysical Research Letters
Isoprene emissions from tropical plants under moderate conditions are more temperature‐sensitive than temperate plants and current model predictions. However, the effect of extreme heatwaves on this sensitivity remains uncertain.
Jianqiang Zeng, Yanli Zhang, Weihua Pang, Haofan Ran, Hao Guo, Yuting Lu, Wei Song, Xinming Wang   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

High Pressure Enhances the Growth Rate of the Thermophilic Archaebacterium Methanococcus thermolithotrophicus without Extending Its Temperature Range [PDF]

, 1988
Temperature and hydrostatic pressure are essential in determining the assemblage of species in their specific biotopes. To evaluate the effect of high pressure on the range of viability of thermophiles, the pressure and temperature dependence of the ...
Lüdemann, Hans-Dietrich, Jaenicke, Rainer, Stetter, Karl Otto, König, Helmut, Bernhardt, Günther   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The temperature sensitivity of soil: microbial biodiversity, growth, and carbon mineralization

The ISME Journal, 2021
Chao Wang, E. Morrissey, Rebecca L. Mau, M. Hayer, J. Piñeiro, M. Mack, J. Marks, S. Bell, S. Miller, E. Schwartz, P. Dijkstra, B. Koch, B. Stone, A. Purcell, S. Blazewicz, K. Hofmockel, J. Pett-Ridge, B. Hungate   +17 more
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source