Results 131 to 140 of about 1,113,211 (316)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Temperature sensitivity of soil respiration to nitrogen and phosphorous fertilization: Does soil initial fertility matter?

, 2018
Temperature sensitivity of soil respiration (Q10) is an important parameter when modeling the effects of global warming on terrestrial ecosystem carbon release.
Qiqi Sun, Lanlan Du, Shengli Guo, Ying Wang, Yaxian Hu, Man Zhao, Xin Gao, Rui Wang   +7 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Thermal Evaluation of the Initial Concept 3.X Vehicle at Mach 7

Energies
High-speed global surface temperature distributions and heat flux measurements on the Initial Concept 3.X vehicle (IC3X) model were investigated at the UTSA Mach 7 wind tunnel, examining angles of attack of 0° and 5° at a freestream unit Reynolds number (
Abinayaa Dhanagopal, Nathan S. Strasser, Angelina Andrade, Kevin R. Posladek, Eugene N. A. Hoffman, Christopher S. Combs   +5 more
doaj   +1 more source

A Three-Layer Atmosphere-Ocean Time Series Model of Global Climate Change [PDF]

Time series models of global climate change have tended to estimate a low climate sensitivity and a fast adjustment rate to equilibrium. These results appear to be biased by omission of a key variable - heat stored in the ocean.
David I. Stern
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Causal hybrid modeling with double machine learning—applications in carbon flux modeling

Machine Learning: Science and Technology
Hybrid modeling integrates machine learning with scientific knowledge to enhance interpretability, generalization, and adherence to natural laws. Nevertheless, equifinality and regularization biases pose challenges in hybrid modeling to achieve these ...
Kai-Hendrik Cohrs, Gherardo Varando, Nuno Carvalhais, Markus Reichstein, Gustau Camps-Valls   +4 more
doaj   +1 more source

Evaluation and application of low damage guar gum fracturing fluid in deep coalbed methane reservoirs

Meikuang Anquan
An evaluation of low damage guar gum fracturing fluid system based on deep coalbed methane reservoir stimulation was carried out, its on-site application research was conducted.
Yongcheng ZHANG, Liangliang LIU, Dehui LI, Yang BAI, Wei ZHANG, Yuxia QIN   +5 more
doaj   +1 more source

Investigating the factors influencing RDX shock sensitivity [PDF]

, 2012
The shock sensitivity of RDX (cyclotrimethylenetrinitramine) is dependent upon factors including crystal size, morphology, internal defects, surface defects and HMX content.
Hudson, R J
core