Results 111 to 120 of about 16,749,992 (355)

Millennial temperature reconstruction intercomparison and evaluation [PDF]

, 2006
There has been considerable recent interest in paleoclimate reconstructions of the temperature history of the last millennium. A wide variety of techniques have been used.
J. Esper, Weber, SL, Juckes, MN, Allen, Myles, M. R. Allen, Juckes, M. N., M. N. Juckes, S. L. Weber, Briffa, KR, G. C. Hegerl, Esper, J., A. Moberg, Hegerl, GC, Weber, S. L., T. J. Osborn, Esper, J, Hegerl, G. C., Osborn, TJ, Allen, M. R., Moberg, A., Briffa, K. R., Osborn, T. J., Zorita, E., Moberg, A, K. R. Briffa, Allen, Myles R., Allen, MR   +26 more
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Temperature response of ammonia and greenhouse gas emission from manure amended silty clay soil

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2018
Soil temperature plays an important role in organic matter decomposition, thus likely to affect ammonia and gaseous emission from land application of manure.
Suresh Niraula, Shafiqur Rahman, Amitava Chatterjee   +2 more
doaj   +1 more source

Snapshot of methanogen sensitivity to temperature in Zoige wetland from Tibetan plateau

Frontiers in Microbiology, 2015
Zoige wetland in Tibetan plateau represents a cold environment at high altitude where significant methane emission has been observed. However, it remains unknown how the production and emission of CH4 from Zoige wetland will respond to a warming climate.
Li eFu, Tianze eSong, Yahai eLu, Yahai eLu   +3 more
doaj   +1 more source

Long-term fertilization increases the temperature sensitivity of OC mineralization in soil aggregates of a highland agroecosystem

, 2016
The mineralization of aggregate-associated organic carbon (OC) and the effect of long-term fertilization on its temperature sensitivity have not been addressed, but are critical for understandingOC sequestration and dynamics in agricultural soil ...
MingdeHao, Tiane Ma, Mingan Shao, Xingchang Zhang, YuhongWang, YanchunWei, XiaorongWei   +6 more
core   +1 more source

Climate change detection and attribution: Beyond mean temperature signals [PDF]

, 2006
A significant influence of anthropogenic forcing has been detected in global- and continental-scale surface temperature, temperature of the free atmosphere, and global ocean heat uptake.
Xuebin Zhang, Hegerl, Gabriele C., Allen, M., Gillett, Nathan P., Bindoff, N. L., David Karoly, Nathaniel L. Bindoff, Hegerl, G. C., Karoly, D., Karoly, David J., Zwiers, Francis W., Gabriele C. Hegerl, Francis Zwiers, Karl, T. R., Bindoff, Nathaniel L., Karl, Thomas R., Zwiers, F., Zhang, X. B., Nathan Gillett, Thomas R. Karl, Myles Allen, Allen, Myles R., Gillett, N., Zhang, Xuebin   +23 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Variation Characteristics of Major Grain Crop Yields and Their Response to Climate Change in Heilongjiang Province, China

Agriculture
Heilongjiang Province is China’s largest commercial grain-producing base, meaning that understanding the stability and climatic sensitivity of its major crops are essential for national food security.
Deqiang Qi, Guanglian Ma, Chenghuang Yu, Jiansong Wang, Hongyu Li, Xiaoyan Liang, Hongtao Xiang   +6 more
doaj   +1 more source

Usefulness of high-sensitivity IL-6 measurement for clinical characterization of patients with coronary artery disease

, 2005
Interleukin 6 (IL-6) may represent an early marker of inflammatory activation and may be useful to ameliorate risk stratification in patients with ischemic heart disease.
BATTAGLIA D, ZUCCHELLI G.C. USEFULNESS OF HIGH SENSITIVITY, LUBRANO V, MARRACCINI P, COCCI, FRANCA, PAPA A   +5 more
core  

Batch fermentation process: Modelling and direct sensitivity analysis [PDF]

, 2009
Based on a nonlinear model, this article realizes an investigation of dynamic behaviour of a batch fermentation process using direct sensitivity analysis (DSA).
Sipos, Anca, A. Sipos, Agachi, Paul Şerban, Agachi, P., Sipos, A., Strehaiano, P., X. Meyer, P. Strehaiano, Meyer, Xuân-Mi, Meyer, X., Strehaiano, Pierre, P. Agachi   +11 more
core   +1 more source