Results 101 to 110 of about 1,113,211 (316)

Fabricating optical fibre-top cantilevers for temperature sensing

, 2014
In this paper, we propose techniques to fabricate micro-cantilevers onto the end of standard single mode optical fibres using a combination of picosecond laser machining and focused ion beam milling techniques and demonstrate their use as temperature ...
Li, Jun, Sun, Jining, Miliar, M M, Hand, D P; id_orcid, Macpherson, W N; id_orcid, Albri, F, Maier, R R J; id_orcid   +6 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

In vivo comparative analysis of live influenza vaccine candidates obtained by reverse genetics and classical reassortment

Инфекция и иммунитет
Difficulties identified in recent years while preparing reassortant live influenza vaccine (LAIV) strains related to the specific biological properties of currently circulating epidemic influenza viruses, necessitate the search for alternative ...
Natalie V. Larionova, Irina V. Kiseleva, Maya K. Vorsina, Anna K. Chistyakova, Ekaterina A. Stepanova, Larisa G. Rudenko, Ekaterina A. Bazhenova   +6 more
doaj   +1 more source

Fiber Bragg grating pressure sensor with ultrahigh sensitivity and reduced temperature sensitivity

, 2009
A fiber Bragg grating (FBG) pressure sensing scheme based on a flat diaphragm and an L-shaped lever is presented. An L-shaped lever transfers the pressure-induced defection of the flat diaphragm to the axial elongation of the FBG.
Zhang WT Chinese Acad Sci Inst Semicond Optoelect Syst Lab POB 912 Beijing 100083 Peoples R China. E-mail Address: zhangwt@semi.ac.cn, Zhang WT, Liu YL, Li F   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Atmospheric Feedbacks Reverse the Sensitivity of Modeled Photosynthesis to Stomatal Function

Journal of Advances in Modeling Earth Systems
Stomata mediate fluxes of carbon and water between terrestrial plants and the atmosphere. These fluxes are governed by stomatal function and can be modulated in many Earth system models by an empirical parameter within the calculation of stomatal ...
Amy X. Liu, Claire M. Zarakas, Benjamin G. Buchovecky, Linnia R. Hawkins, Alana S. Cordak, Ashley E. Cornish, Marja Haagsma, Gabriel J. Kooperman, Chris J. Still, Charles D. Koven, Alexander J. Turner, David S. Battisti, James T. Randerson, Forrest M. Hoffman, Abigail L. S. Swann   +14 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The possible use of combined electrical impedance and ultrasound velocity measurements for the non-invasive measurement of temperature during mild hyperthermia [PDF]

, 2013
This paper explores the possibility of using combined measurements of electrical impedance and changes in ultrasound time of flight for determining deep body temperature during mild hyperthermia. Simultaneous electrical impedance spectra (1 kHz–1024 kHz)
Hale, Rebecca, Taylor, Matthew S., Wilson, Adrian J., Islam, Naimul   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Height‐Dependent Sensitivity of Cloud Scales to Surface Temperature Anomaly Observed by Active Satellites

Geophysical Research Letters
As a key macrophysical property, cloud horizontal scale plays a critical role in cloud radiative effect (CRE), precipitation and convective structures.
Lijie Zhang, Jiming Li, Zhenyu Cao, Sihang Xu, Qiudi Xu, Bida Jian, Yang Wang, Yuan Wang   +7 more
doaj   +1 more source