Results 51 to 60 of about 1,113,211 (316)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In the present work, the uniaxial compressive mechanical proper\ties of ultrafine grained (UFG) aluminum produced by equal channel angular pressing method were investigated experimentally over a wide temperatures ranging from 77 to 473 K under both quasi-
Jin Su +5 more
doaj +1 more source
Plant species α-diversity is closely correlated with ecosystem structures and functions. However, whether climate change and human activities will reduce plant species α-diversity remains controversial.
Shaolin Huang, Gang Fu
doaj +1 more source
Quantitative sensitivity analysis of surface attached optical fiber strain sensor [PDF]
Optical fiber strain sensors, in particular, the fiber Bragg grating (FBG) type, are widely applied in different applications. The most common installation method is surface-attached.
Wan, KT
core +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Wetlands store a large amount of carbon (C) and many are vulnerable to potential global warming. It is critical to quantify the temperature sensitivity of soil nitrogen (N) and C mineralization in response to external labile C or N addition in different ...
Chunmei Wang, Yunyun Zhang, Yun Li
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Active compensating method of sensitivity temperature drift of convection-based Tilt sensor
When environment temperature is changed, the properties of convection-based tilt sensors are changed, which is so-called sensitivity temperature drift. Methods of sensitivity compensation are introduced according to mechanism of this kind of tilt sensor:
Peng SL(彭世镠) +3 more
core +1 more source

