Results 71 to 80 of about 1,016,447 (267)

Atmospheric Feedbacks Reverse the Sensitivity of Modeled Photosynthesis to Stomatal Function

open access: yesJournal of Advances in Modeling Earth Systems
Stomata mediate fluxes of carbon and water between terrestrial plants and the atmosphere. These fluxes are governed by stomatal function and can be modulated in many Earth system models by an empirical parameter within the calculation of stomatal ...
Amy X. Liu   +14 more
doaj   +1 more source

In vivo comparative analysis of live influenza vaccine candidates obtained by reverse genetics and classical reassortment

open access: yesИнфекция и иммунитет
Difficulties identified in recent years while preparing reassortant live influenza vaccine (LAIV) strains related to the specific biological properties of currently circulating epidemic influenza viruses, necessitate the search for alternative ...
Natalie V. Larionova   +6 more
doaj   +1 more source

THE EFFECT OF LOW TEMPERATURES ON THE SENSITIVITY OF RADIOMETERS [PDF]

open access: yesProceedings of the National Academy of Sciences, 1930
The behavior of radiometers at low temperatures, besides being of some interest to the theoretical physicist,(2) is of considerable importance to one desiring to carry radiant energy measurements to an extreme limit. Various workers have already pushed the sensitivity of such instruments as the thermocouple, radio micrometer, and radiometer into the ...
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Height‐Dependent Sensitivity of Cloud Scales to Surface Temperature Anomaly Observed by Active Satellites

open access: yesGeophysical Research Letters
As a key macrophysical property, cloud horizontal scale plays a critical role in cloud radiative effect (CRE), precipitation and convective structures.
Lijie Zhang   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Heatwaves Suppress Isoprene Emission Optima in Subtropical Eucalyptus: Implications for Biogenic VOC Modeling Under Extreme Thermal Events

open access: yesGeophysical Research Letters
Isoprene emissions from tropical plants under moderate conditions are more temperature‐sensitive than temperate plants and current model predictions. However, the effect of extreme heatwaves on this sensitivity remains uncertain.
Jianqiang Zeng   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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