Results 101 to 110 of about 1,206,514 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Measuring temperature of the ice surface during its formation by using infrared instrumentation [PDF]

, 2007
A non-destructive remote sensing technique was used to measure the surface temperature of a thin macroscopic water film flowing on a growing asymmetric ice accretion during its formation inside an icing research wind tunnel.
Kollar, László E., Farzaneh, Masoud, Karev, Anatolij R.   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Enhanced Temperature Stability of Coercivity in Sintered Permanent Magnet by Substitution of Ce for Didymium

, 2016
Effects of partial substitution of Ce for didymium (Pr-Nd alloy, abbreviated to Di) on elevated temperature magnetic properties in sintered (Di(1-x)Ce(x))(27.5)Dy3Al0.1Cu0.1Febal.B (wt.%, x = 0 similar to 0.56) magnets were investigated in this paper ...
Lee, Dong, Guo, Shuai, Liu, Jian, Yan, Changjiang, Chen, Ling, Chen, Renjie, Yan, Aru   +6 more
core  

Analysis of the Light Propagation Model of the Optical Voltage Sensor for Suppressing Unreciprocal Errors

Sensors, 2017
An improved temperature-insensitive optical voltage sensor (OVS) with a reciprocal dual-crystal sensing method is proposed. The inducing principle of OVS reciprocity degradation is expounded by taking the different temperature fields of two crystals and ...
Hui Li, Zhida Fu, Liying Liu, Zhili Lin, Wei Deng, Lishuang Feng   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Improved design of passive wireless sensor for ultra-high temperature environment and its back-end circuit measurement system

Frontiers in Mechanical Engineering
IntroductionAn improved passive wireless sensor is presented for ultra-high temperature environments, utilizing a folded Complementary Split-Ring Resonator (CSRR) structure. A dedicated back-end circuit measurement system is also developed to support the
Deming Li, Deming Li
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Temperature stability of rabies neutralizing antibodies

Journal of Immunological Methods
Rabies serology is most importantly done to evaluate immune response following vaccine administration in patients who have been exposed to rabies or are highly likely to be. When detecting antibodies after vaccination it is best to target rabies neutralizing antibodies specifically. Clinical laboratories performing this testing are required to uphold a
Nicholas J, Jones, Kim A, Appler, Jodie A, Jarvis, Alexander C, Keyel, April D, Davis   +4 more
openaire   +2 more sources