Results 111 to 120 of about 1,206,514 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Low temperature heat capacity and thermal stability of nanocrystalline nickel

, 2002
The heat capacity (C-p) of nanocrystalline nickel (nc-Ni, 40 mn crystallite size) has been measured over the temperature range of 78-370 K with a high-resolution automated adiabatic calorimeter.
Liu, BP, Liang, DB, Wang, L, Tan, ZC, Meng, SH   +4 more
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Ultralight, Recoverable, and High-Temperature-Resistant SiC Nanowire Aerogel

, 2018
Ultralight ceramic aerogels with the property combination of recoverable compressibility and excellent high-temperature stability are attractive for use in harsh environments.
Zhongqi Shi (1396384), Xingyu Fan (4916266), Min Niu (1862923), Sheng-Wu Guo (4916269), Lei Su (361548), Hongjie Wang (54357), Mingbo Ma (4916263)   +6 more
core   +1 more source

Nonlinear stability analysis of convection for fluids with exponentially temperature dependent viscosity

, 1994
A nonlinear energy stability analysis of the onset of convection for fluids with viscosity depending exponentially on temperature, is performed.
CAPONE, FLORINDA, GENTILE, MAURIZIO
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On alloying and low-temperature stability of thin, supported PdAg membranes

, 2012
Electroless plating is the technically most facile and most frequently studied method for preparation of PdAg/ceramic composite membranes. Limited high-temperature stability of such membranes requires alloying of sequentially deposited Pd and Ag layers ...
Xu, Hengyong, Goldbach, Andreas, 哥德巴赫, 徐恒泳, Zeng, Gaofeng, Shi, Lei   +5 more
core   +1 more source

Simultaneous achievement of large strain, low hysteresis, and high-temperature stability in textured BT-based piezoelectric ceramics

Journal of Advanced Ceramics
BaTiO3 (BT)-based piezoceramics with large temperature-stable strains and low hysteresis are urgently needed for high-precision actuators because of increasing environmental problems. Here, tetragonal [001]c-textured (Ba0.98Ca0.02)(Ti0.96Sn0.04)O3 (BCTS)
Xiyue Zhang, Zhe Wang, Peng Li, Yingchun Liu, Juan Du, Jigong Hao, Wei Li, Jiwei Zhai   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

BioTuner: The Structural and Genomic Studies of Protein Stability

, 2009
[[abstract]]The demand of stable protein is not only in a laboratory , but also in the industry. Always it is hard to get protein stability information in a faster and more effective way before experiments, which leads to the fact that experiments often ...
WU JIA YI
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