Results 151 to 160 of about 1,206,514 (314)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tests of predictions made by the Equilibrium Model for the effect of temperature on enzyme activity

, 2008
The Classical Model describing the effects of temperature on enzyme activity consists of two processes: the catalytic reaction defined by ΔG cat and irreversible inactivation defined by ΔG inact, this model however, does not account for the observed ...
Oudshoorn, Matthew Leslie
core  

Tb³⁺-Doped LGS Crystals: Crystal Growth and Electro-Elastic Features

Crystals
Piezoelectric materials have garnered significant attention due to their diverse applications in technologies such as sensors, actuators, and energy-harvesting systems. This study focuses on the growth and characterization of Tb3+-doped La3Ga5SiO14 (LGS)
Nianlong Zhang, Jipeng Wu, Hengyuan Zhang, Feifei Chen, Fapeng Yu, Li Sun, Xian Zhao   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exceptional electrostrain with minimal hysteresis and superior temperature stability under low electric field in KNN-based lead-free piezoceramics

Journal of Advanced Ceramics
Over the past two decades, (K0.5Na0.5)NbO3 (KNN)-based lead-free piezoelectric ceramics have made significant progress. However, attaining a high electrostrain with remarkable temperature stability and minimal hysteresis under low electric fields has ...
Huan Liu, Yijin Hao, Ziqi Yang, Tianyi Feng, Bin Su, Xin Zhang, Mengping Xue, Bo-Ping Zhang, Jing-Feng Li   +8 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

High‐Entropy Ferroelectric‐Ferroelastic Hybrid for Ultrahigh and Temperature‐Insensitive Dielectric Energy Storage

Advanced Science
Electrostatic energy storage plays an irreplaceable role in the pulse power systems, thus the development of capacitors with ultrahigh and thermal stable energy storage properties meets the requirement of next‐generation devices.
Xuefan Zhou, He Qi, Yingchun Su, Zhimin Huang, Yan Zhang, Hang Luo, Dou Zhang   +6 more
doaj   +1 more source

Effect of A/B sites co-doping on the structure, electric and dielectric properties of CaTiSiO5 ceramics

Journal of Advanced Dielectrics
Dielectrics with high permittivity and temperature stability are important for the development of high-temperature multilayer ceramic capacitors (MLCCs). In this study, Ca[Formula: see text]NaxTi[Formula: see text]NbxSiO5 (abbreviated as CTS[Formula: see
Hanwen Ni, Zichen He, Zhifu Liu
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Production of Lactase by Trichoderma sp.

Food Technology and Biotechnology, 2004
In order to find an alternative fungal source, 13 different fungi (Aspergillus, Trichoderma, Penicillium, Rhizopus and Fusarium sp.) were cultured in lactase production medium at 30 °C and 150 rpm for 6 days.
Nilufer Aksoz, Isil Seyis
doaj