Results 91 to 100 of about 115,907 (299)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Progresses in Pneumatic Temperature Control Technique for Ultra-Precise Control and Measurement of Thermal Environment [PDF]

한국정밀공학회지
In this paper, we introduce a new pneumatic temperature control technique and its application to precision thermometry. The method controls temperature by adjusting gas pressure through the unique thermohydraulic linkage of the pressure-controlled loop ...
Bomi Nam, Wukchul Joung
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research on Performance Optimization of Running Air-cooled Heat Pipe Radiator Based on Temperature Equalization Technology

机车电传动, 2021
In view of the high risk of overheat for traditional air-cooled straight pipe heat pipe radiators in the low-speed operation of subway, a new type of heat pipe radiator that can effectively solve the problem above was proposed.
Zhiyong WU, Xiong WANG, Nan HUANG, Guomeng SONG, Hongfeng WANG, Mingyi CHEN, Jie ZOU   +6 more
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Temperature uniformity of microdroplet heated by Rayleigh Surface Acoustic Wave in view of biological reaction [PDF]

, 2013
IEEE International Ultrasonics Symposium (IUS), Prague, CZECH REPUBLIC, JUL 21-25, 2013International audienceIn this paper, we have studied the temperature uniformity of microdroplet heated by Rayleigh surface acoustic wave for discrete microfluidic ...
T. Roux-Marchand, Elmazria, Omar, F. Sarry, Beyssen, Denis, O. Elmazria, Sarry, Frédéric, D. Beyssen, Roux-Marchand, T.   +7 more
core   +1 more source

Optimization of Synthetic Jet Position for Heat Transfer Enhancement and Temperature Uniformity of a Heated Wall in Micro-Channels

Journal of Applied Fluid Mechanics, 2019
In this study, the synthetic jet position was optimized to obtain the maximum rate of heat transfer and the best state of temperature uniformity on a heated surface in micro-channels.
J. Khaleghinia, F. Kowsary, C. Aghanajafi   +2 more
doaj  

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Design and Temperature Uniformity Optimization of Electromagnetic Heating Hot Plate for Tire Vulcanizing Machine [PDF]

To address the issue of uneven temperature distribution during the tire vulcanization process based on electromagnetic heating, this study focuses on the hot plate of a tire vulcanizing machine.
Mengjun Chen, Jiuliang Gan, Houhui Xia, Rongjiang Tang, Zhengliang Xia   +4 more
core   +1 more source