Results 81 to 90 of about 365,839 (309)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental analysis of temperature uniformity in a vertical smart-farm with radiant cooling panels

International Journal of Air-Conditioning and Refrigeration
The vertical smart-farm, characterized by multi-layer cultivation structures, predominantly employs a convection cooling system to establish crop growth environments.
Hye-Jin Cho, Chang-Ho Jeong
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Experimental investigation of non-uniform heating effect on flow boiling instabilities in a microchannel-based heat sink [PDF]

, 2011
Copyright @ 2011 ElsevierTwo-phase flow boiling in microchannels is one of the most promising cooling technologies for coping with high heat fluxes produced by the next generation of central processor units (CPUs).
A.J. Walton, Bergles, Bogojevic, D. Bogojevic, D.B.R. Kenning, G. Cummins, H. Lin, Hetsroni, K. Sefiane, Kandlikar, Kenning, Kosar, Lin, Qu, Revellin, T.G. Karayiannis, Wang, Zhang   +17 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Numerical and Experimental Study of the Temperature Distribution Characteristics of a Cryogenic Non-thermal Equilibrium Cylinder

Zhileng xuebao, 2020
To study the surface temperature distribution characteristics and related control methods of cryogenic non-thermal equilibrium cylinders under complex heat transfer conditions, this study establishes two models of heat transfer enhancement methods ...
Du Yicen, Cheng Ruijie, Wu Shize, Cai Aifeng, Wu Jingyi, Yang Guang   +5 more
doaj  

Analysis of the structure arrangement on the thermal characteristics of Li‐ion battery pack in thermoelectric generator

Energy Science & Engineering, 2020
Traditional automobile exhaust contains a large amount of thermal energy. Thermoelectric generators (TEGs) can store recovered electrical energy into battery packs and supply to vehicle‐mounted electrical equipment. A reasonable battery pack structure is
WenChao Zhu, Changjun Xie, Ying Shi, Weibo Li, Zebo Tang   +4 more
doaj   +1 more source

A Simple Method to Eliminate Shielding Currents Generated when Magnetization is Perpendicular to Superconducting Tapes Wound into Coils

, 2011
Application of an external AC magnetic field parallel to superconducting tapes helps in eliminating the magnetization caused by the shielding current induced in the flat faces of the tapes.
Funaki, Kazuo, Kajikawa, Kazuhiro
core   +1 more source

The monitoring system for the aerogel Cherenkov counter of the BELLE detector [PDF]

, 1998
We report on a design and performances of a monitoring system developed for the aerogel Cherenkov counters (ACC) of the BELLE detector. The system consists of blue LEDs, a diffuser box, and optical distributors which distribute the LED light to the ACC ...
A. Murakami, Adachi, Anton, Enomoto, H. Hattori, I. Adachi, Iijima, Iijima, K. Kaneda, K. Suzuki, M. Watanabe, M.H.R. Khan, Peitzmann, R. Enomoto, R. Kawabata, R. Suda, T. Iijima, T. Kuniya, T. Ooba, T. Sumiyoshi   +19 more
core   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source