Results 61 to 70 of about 365,839 (309)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Forced Convection of Al₂O₃–Cu, TiO₂–SiO₂, FWCNT–Fe₃O₄, and ND–Fe₃O₄ Hybrid Nanofluid in Porous Media

Energies, 2020
Adding nanoparticles to fluid has led to a new class of fluids named as nanofluids. Different concentrations and its effective cooling have attracted many engineering applications to test this new fluid.
M. Z. Saghir, M. M. Rahman
doaj   +1 more source

Temperature uniformity optimization with power-frequency coordinated variation in multi-source microwave based on sequential quadratic programming

High Temperature Materials and Processes, 2023
The focus of this study is to regulate the variation in the input parameters of multiple microwave sources in a high-frequency multimode resonant heating system to achieve uniform heating.
Yang Biao, Han Zemin, Cheng Cheng, Gao Hao, Wu Zhaogang   +4 more
doaj   +1 more source

Improved thermal performance of a large laminated lithium-ion power battery by reciprocating air flow [PDF]

, 2019
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Thermal safety issues are increasingly critical for large-size laminated Lithium-Ion Batteries (LIBs ...
Ji, S., Li, K., Tian, Y., Wang, J., Wang, S., Wu, Y.   +5 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Numerical Study on Thermal Design of a Large-Area Hot Plate with Heating and Cooling Capability for Thermal Nanoimprint Lithography

Applied Sciences, 2019
A numerical study is conducted on the thermal performance of a large-area hot plate specifically designed as a heating and cooling tool for thermal nanoimprint lithography processes.
Gyujin Park, Changhee Lee
doaj   +1 more source

Measuring the energy handling capability of metal oxide varistors [PDF]

, 2001
Metal oxide varistors are widely used in many power electronics circuits to protect against transient over voltages. Certain applications are very demanding on the energy handling capability of the varistors.
Ahmed, M. M. R., Penlington, Roger, Putrus, G.A., Ran, L.   +3 more
core   +1 more source

Testing Gaussian random hypothesis with the cosmic microwave background temperature anisotropies in the three-year WMAP data

, 2006
We test the hypothesis that the temperature of the cosmic microwave background is consistent with a Gaussian random field defined on the celestial sphere, using de-biased internal linear combination (DILC) map produced from the 3-year WMAP data.
Bond J. R., Kuiper N. H., Lung‐Yih Chiang, Pavel D. Naselsky, Peter Coles   +4 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source