Results 41 to 50 of about 365,839 (309)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Applied SciencesNew energy vehicles (NEVs) rely heavily on Insulated-Gate Bipolar Transistors (IGBTs) to perform frequent battery voltage conversions for operations such as acceleration, deceleration, and hill climbing.
Chuncen Wu, Feng Wang, Yifan Song
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
EnergiesTo address the poor temperature uniformity of conventional heating systems in photovoltaic module laminators, this paper proposes an electromagnetic induction heating method incorporating temperature control. An electromagnetic–thermal coupling model was
Lei Shi +4 more
doaj +1 more source
Infrared imaging investigation of temperature fluctuation and spatial distribution for a large laminated lithium ion power battery [PDF]
, 2019 The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The present study investigates the thermal behaviors of a naturally cooled NCM-type LIB (LiNi1−x−yCoxMnyO2 ...
Ji, S. +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Temperature Uniformity in Cross-Flow Double-Layered Microchannel Heat Sinks
Fluids, 2020 An in-house finite element method (FEM) procedure is used to carry out a numerical study on the thermal behavior of cross-flow double-layered microchannel heat sinks with an unequal number of microchannels in the two layers.
Carlo Nonino, Stefano Savino
doaj +1 more source
A Solution to the electroweak horizon problem in the R_h=ct universe
, 2018 Particle physics suggests that the Universe may have undergone several phase transitions, including the well-known inflationary event associated with the separation of the strong and electroweak forces in grand unified theories.
Melia, Fulvio
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Research and Optimization of Liquid Cooling Plate for High-heat-flux Components
Zhileng xuebao, 2021 Fluid cooling plates are widely used in the heat dissipation of high-density components, which imposes stricter requirements for the temperature uniformity of the plate surface.
Zhan Binfei +5 more
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