Results 41 to 50 of about 97,327 (246)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Forced Convection of Al₂O₃–Cu, TiO₂–SiO₂, FWCNT–Fe₃O₄, and ND–Fe₃O₄ Hybrid Nanofluid in Porous Media

Energies, 2020
Adding nanoparticles to fluid has led to a new class of fluids named as nanofluids. Different concentrations and its effective cooling have attracted many engineering applications to test this new fluid.
M. Z. Saghir, M. M. Rahman
doaj   +1 more source

Temperature uniformity optimization with power-frequency coordinated variation in multi-source microwave based on sequential quadratic programming

High Temperature Materials and Processes, 2023
The focus of this study is to regulate the variation in the input parameters of multiple microwave sources in a high-frequency multimode resonant heating system to achieve uniform heating.
Yang Biao, Han Zemin, Cheng Cheng, Gao Hao, Wu Zhaogang   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Uniformalization of Temperature Field in Agitated Reactors.

Chemical engineering, 1970
パドル翼, アンカー翼, ゲート翼, ヘリカルリボン翼を持った撹拌反応槽でスチレンの塊状重合を行なわせて槽内の温度変化を測定した結果, ヘリカルリボン翼が温度の均一化に最良であることがわかった。また次元解析により新しい混合無次元数を導出し, 温度および濃度の均一化においてこの無次元数が撹拌翼の種類によらずほぼ一定値をとることを確かめた。最後に内部発熱のある場合の撹拌槽内の温度むらもまたこの混合無次元数に支配されることがわかった。
Tokuro Mizushina, Ryuzo Ito, Setsuro Hiraoka, Junkichi Watanabe   +3 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Investigation on Thermal Performance of a Battery Pack Cooled by Refrigerant R134a in Ribbed Cooling Channels

Energies
This study numerically investigates the thermal performance of a refrigerant-based battery thermal management system (BTMS) under various operating conditions.
Tieyu Gao, Jiadian Wang, Haonan Sha, Hao Yang, Chenguang Lai, Xiaojin Fu, Guangtao Zhai, Junxiong Zeng   +7 more
doaj   +1 more source

Numerical Study on Thermal Design of a Large-Area Hot Plate with Heating and Cooling Capability for Thermal Nanoimprint Lithography

Applied Sciences, 2019
A numerical study is conducted on the thermal performance of a large-area hot plate specifically designed as a heating and cooling tool for thermal nanoimprint lithography processes.
Gyujin Park, Changhee Lee
doaj   +1 more source