Results 51 to 60 of about 97,327 (246)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Effects of Endwall Fillet and Bulb on the Temperature Uniformity of Pin-Fined Microchannel

Entropy, 2017
Endwall fillet and bulb structures are proposed in this research to improve the temperature uniformity of pin-fined microchannels. The periodical laminar flow and heat transfer performances are investigated under different Reynolds numbers and radius of ...
Zhiliang Pan, Ping Li, Jinxing Li, Yanping Li   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Isothermal extrusion using a uniform temperature billet

Journal of Japan Institute of Light Metals, 2004
Isothermal extrusion is a method of maintaining constant temperature of an extruded section in the bearing zone of the die in order to get a high steady qualities in mechanical properties. Isopressure extrusion is a method of maintaining the load on the die constant throughout the ram stroke in order to get a high steady qualities in dimensions of ...
Masaya TAKAHASHI, Takeshi YONEYAMA
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Experimental analysis of temperature uniformity in a vertical smart-farm with radiant cooling panels

International Journal of Air-Conditioning and Refrigeration
The vertical smart-farm, characterized by multi-layer cultivation structures, predominantly employs a convection cooling system to establish crop growth environments.
Hye-Jin Cho, Chang-Ho Jeong
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effect of Ablation Material and Deuterium-tritium Ice Profile on Cryogenic Target Thermal Fields

Zhileng xuebao, 2020
The uniformity of deuterium-tritium (DT) ice layer plays a key role in the successful ignition of indirective inertial confinement fusion (ICF), and is closely related to the temperature field of the cryogenic target, especially the temperature ...
Li Cui, Ding Lan, Li Yanzhong, Xin Yi, Zhao Jun   +4 more
doaj  

Analysis of the structure arrangement on the thermal characteristics of Li‐ion battery pack in thermoelectric generator

Energy Science & Engineering, 2020
Traditional automobile exhaust contains a large amount of thermal energy. Thermoelectric generators (TEGs) can store recovered electrical energy into battery packs and supply to vehicle‐mounted electrical equipment. A reasonable battery pack structure is
WenChao Zhu, Changjun Xie, Ying Shi, Weibo Li, Zebo Tang   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source