Results 101 to 110 of about 2,039,832 (291)

Reconstruction of deglacial sea surface temperatures in the tropical Pacific from selective analysis of a fossil coral [PDF]

, 2005
The Sr/Ca of coral skeletons demonstrates potential as an indicator of sea surface temperatures (SSTs). However, the glacial-interglacial SST ranges predicted from Sr/Ca of fossil corals are usually higher than from other marine proxies.
Finch, A. A., Ellam, R, Ellam, R. M., Allison, N, Newville, M., Sutton, S R, Sutton, S. R., Finch, A A, Tudhope, A W, Newville, M, Ellam, R M, Tudhope, A. W., Allison, N.   +12 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of Initial Biomass Concentration on the Growth Kinetics of Chlorella vulgaris in Cylindrical Photobioreactors

Bioengineering
Microalgae of the genus Chlorella are widely used in biotechnology for biofuel production, wastewater treatment, and biomass generation. This study examined the effect of initial biomass concentration on the growth kinetics of Chlorella vulgaris ...
Vadim A. Pavlov, Anatoly V. Grigorenko, Elizaveta M. Kovalenko, Marina E. Vavilkina, Mikhail S. Vlaskin   +4 more
doaj   +1 more source

Coulomb stable structures of charged dust particles in a dynamical trap at atmospheric pressure in air

New Journal of Physics, 2013
A mathematical simulation of a dust particle's behavior in the electrodynamic linear quadrupole trap with closing end electrodes allowed us to reveal several features of the phenomena.
L M Vasilyak, V I Vladimirov, L V Deputatova, D S Lapitsky, V I Molotkov, V Ya Pecherkin, V S Filinov, V E Fortov   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Growth of Limnospira platensis Under Elevated CO₂ with the Addition of Sodium Selenite

Plants
Cultivation of L. platensis under elevated CO2 ensures CO2 biofixation, while adding Na2SeO3 to the culture medium, produces valuable Se-enriched biomass.
Anatoly V. Grigorenko, Elizaveta M. Kovalenko, Marina E. Vavilkina, Maksim A. Kravets, Mikhail S. Vlaskin   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Generation of Simulated Daily Precipitation and Air and Soil Temperatures, January 2000 [PDF]

, 2000
This paper describes a maximum likelihood method using historical weather data to estimate a parametric model of daily precipitation and maximum and minimum air temperatures.

core  

Picosecond Dynamics of Selective Ablation in a Ni/Al Multilayer Thin Film Induced by a Femtosecond Laser Pulse

Nanomaterials
In recent decades, high-precision processing with ultrashort laser pulses has been progressively applied in highly efficient surface modification technologies for new multilayer nanomaterials widely used in industry.
Sergey I. Ashitkov, Pavel S. Komarov, Evgenia V. Struleva, Mikhail A. Ovchinnikov, Dmitry S. Sitnikov   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source