Results 61 to 70 of about 3,634,731 (300)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

CELLULAR AND SUBCELLULAR LEVEL INVESTIGATION OF BIOLOGICAL OBJECTS BY MEANS OF FEMTOSECOND LASER OPTICAL TWEEZERS-SCALPEL

Вестник трансплантологии и искусственных органов, 2009
The aim of this work was developing of elements of the precise three-dimensional positioning technology of one or several micron and submicron size biological objects.
M. M. Rakityansky, M. B. Agranat, S. I. Ashitkov, M. N. Karagyaur, D. M. Muhamedzhanova, S. P. Domogatsky, A. V. Ovchinnikov, D. S. Sitnikov, D. V. Stambolsky, I. N. Shevelev   +9 more
doaj   +1 more source

Dry and Wet Events in Andean Populations of Northern Peru: A Case Study of Chachapoyas, Peru

Frontiers in Environmental Science, 2021
Climate change and population growth have heavily impacted the ecosystem’s water resources, essential for anthropogenic activities. These also apply to the Andean city of Chachapoyas, located in the north of Peru, which has gone through a substantial ...
Jesús Rascón, Wildor Gosgot Angeles, Lenin Quiñones Huatangari, Manuel Oliva, Miguel Ángel Barrena Gurbillón   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Anammox bacterial abundance and diversity in different temperatures of purple paddy soils by 13C-DNA stable-isotope probing combined with high-throughput sequencing

Frontiers in Microbiology, 2023
IntroductionAnaerobic ammonium oxidation (anammox) plays a vital role in the global nitrogen cycle by oxidizing ammonium to nitrogen under anaerobic environments.
Zijie Yu, Xinhua He, Zhitong Li, Shuang Zhou, Dalu Guo, Hao Pu, Hongyan Luo   +6 more
doaj   +1 more source

Quantum Ratchets at High Temperatures

, 2004
Using the continued-fraction method we solve the Caldeira-Leggett master equation in the phase-space (Wigner) representation to study Quantum ratchets.
Astumian, Borromeo, Brodier, Caldeira, D. Zueco, García-Palacios, García-Palacios, Grifoni, Hillery, J.L. García-Palacios, Machura, Peguiron, Reimann, Reimann, Risken, Scheidl, Shushin, Stockburger, Weiss, Yukawa, Zurek   +20 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effects of Temperature on Plasma Protein Binding Ratios (PPBRs) of Enrofloxacin and Ciprofloxacin in Yellow Catfish (Pelteobagrus fulvidraco), Grass Carp (Ctenopharyngodon idella), and Largemouth Bass (Micropterus salmoides)

Animals, 2023
The objective of this study was to investigate the PPBRs of EF and CF in the plasma of yellow catfish, grass carp, and largemouth bass at different temperatures with different concentrations. A fast and simple ultrafiltration method was used to determine
Ning Xu, Weiyu Sun, Huan Zhang, Zhi Li, Xiangzhong Luo, Xiaohui Ai, Yongzhen Ding, Bo Cheng   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source