Results 71 to 80 of about 2,039,832 (291)

Biochemical Profile of Limnospira platensis Cultivated Under Elevated CO₂ with the Addition of Sodium Selenite

Plants
Selenium (Se) biofortification of microalgae is a promising strategy for producing functional biomass with enhanced nutritional value. This study evaluates the effect of sodium selenite (Na2SeO3) supplementation to the culture medium on the biochemical ...
Elizaveta M. Kovalenko, Marina E. Vavilkina, Anatoly V. Grigorenko, Maksim A. Kravets, Mikhail S. Vlaskin   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Reconstructed warm season temperatures for Nome, Seward Peninsula, Alaska [PDF]

, 2004
Understanding of past climate variability in the Bering Strait region and adjacent land areas is limited by a paucity of long instrumental and paleoclimatic records. Here we describe a reconstruction of May–August temperatures for Nome, Seward Peninsula,
Frank, D, Jacoby, G, Mashig, E., Frank, D., Mashig, E, Wilson, Rob, Jacoby, G., D'Arrigo, R, D'Arrigo, R.   +8 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epidemic malaria and warmer temperatures in recent decades in an East African highland. [PDF]

, 2010
Climate change impacts on malaria are typically assessed with scenarios for the long-term future. Here we focus instead on the recent past (1970-2003) to address whether warmer temperatures have already increased the incidence of malaria in a highland ...
Mercedes Pascual, Bouma, Menno J., Alonso, David, David Alonso, Menno J. Bouma, Bouma, Menno J, Pascual, Mercedes   +6 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

First year growth in the lithodids Lithodes santolla and Paralomis granulosa reared at different temperatures [PDF]

, 2005
The southern king crab, Lithodes santolla Molina, and stone crab, Paralomis granulosa Jacquinot, inhabit the cold-temperate waters of southernmost South America (southern Chile and Argentina), where stocks of both species are endangered by overfishing ...
Calcagno, J.A., Thatje, S., U. Nettelmann, Lovrich, G.A., Anger, K., S. Thatje, Nettelmann, U., Calcagno, Javier Ángel, G.A. Lovrich, Anger, Klaus, K. Anger, Lovrich, Gustavo Alejandro, Calcagno, J. A., Lovrich, G. A., Nettelmann, Uwe, J.A. Calcagno   +15 more
core   +1 more source