Results 61 to 70 of about 322,385 (264)

Characterization of Nanoporous Surfaces as Templates for Drug Delivery Devices [PDF]

The AAPS Journal, 2009
While the earlier research in drug delivery has been focused on development of drugs, present methodologies target development of the delivery device itself (1–3). Implantable drug delivery devices offer various advantages such as maintenance of therapeutic blood levels, improved patient compliance, and improved safety (4).
Ashish, Rastogi, Tanushree, Bose, Marc D, Feldman, Devang, Patel, Salomon, Stavchansky   +4 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Tamoxifen Delivery System Based on PEGylated Magnetic MCM-41 Silica

Molecules, 2020
Magnetic iron oxide containing MCM-41 silica (MM) with ~300 nm particle size was developed. The MM material before or after template removal was modified with NH2- or COOH-groups and then grafted with PEG chains.
Margarita Popova, Neli Koseva, Ivalina Trendafilova, Hristina Lazarova, Violeta Mitova, Judith Mihály, Denitsa Momekova, Georgi Momekov, Iskra Z. Koleva, Hristiyan A. Aleksandrov, Georgi N. Vayssilov, Ágnes Szegedi   +11 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Facial Synthesis of 3D MnO2 Nanofibers Sponge and Its Application in Supercapacitors

International Journal of Electrochemical Science, 2018
Mesoporous Al2O3 template was facially constructed by hydrolysis of aluminum nitrate solution, and 3D MnO2 foam was fabricated by redox reaction of Mn2+ and MnO4- in the nanoholes of Al2O3 template, followed by sacrificial dissolution of the Al2O3 matrix.
Chuanyun Wan, Haiyan Shen, Xiangrong Ye, Fanhong Wu   +3 more
doaj   +1 more source

Efficient and Accurate Template-based Reconstruction of Deformable Surfaces [PDF]

2024 18th International Conference on Control, Automation, Robotics and Vision (ICARCV)
3D surface reconstruction in deformable environments presents significant challenges. Template-based methods have proven robust for achieving accurate reconstructions by utilising images and textured triangulated meshes as reference data. These methods rely on feature detection in both the reference and current images to establish corresponding points,
Dominik Slomma, Shoudong Huang, Liang Zhao 0003   +2 more
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Ordered Mesoporous Carbons as Novel and Efficient Adsorbent for Dye Removal from Aqueous Solution

Advances in Materials Science and Engineering, 2016
Ordered mesoporous carbons (OMCs) were successfully synthesized by using hard template and soft template methods. These materials were characterized by XRD, TEM, and N2 adsorption-desorption Brunauer-Emmett-Teller (BET).
Phuong T. Dang, Hoa T. H. Nguyen, Canh D. Dao, Giang H. Le, Quang K. Nguyen, Kien T. Nguyen, Hoa T. K. Tran, Tuyen V. Nguyen, Tuan A. Vu   +8 more
doaj   +1 more source