Results 51 to 60 of about 322,385 (264)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A template-free, ultra-adsorbing, high surface area carbonate nanostructure. [PDF]
PLoS ONE, 2013 We report the template-free, low-temperature synthesis of a stable, amorphous, and anhydrous magnesium carbonate nanostructure with pore sizes below 6 nm and a specific surface area of ∼ 800 m(2) g(-1), substantially surpassing the surface area of all ...
Johan Forsgren +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Endodontic management of pulp canal obliteration using a new single-tooth template: A case series
Indian Journal of Dental Research, 2021 Background: Guided Endodontics is suggested as a reliable method for management of teeth with pulp canal obliteration (PCO). The guide used for this usually involves multiple teeth to gain stability but is bulky.
Natanasabapathy Velmurugan +8 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
MTO performance over seed-assisted SAPO-34 zeolites synthesized by reducing template consumption
Journal of Materials Research and Technology, 2020 SAPO-34 samples were prepared via a seeding-induced method with a considerable reduction of template concentration. The resultant SAPO-34 zeolites were investigated by XRD, FESEM, EDS, N2 adsorption, and NH3-TPD analyses.
Sahar Akhgar +2 more
doaj +1 more source
Facile synthesis of porous Mo2C/C composites by using luffa sponge-derived carbon template in molten salt media [PDF]
Royal Society Open Science, 2019 Herein, we report the synthesis of a new type of porous Mo2C/C composite by using luffa sponge-derived carbon template and ammonium molybdate ((NH4)6Mo7O24•4H2O) in molten NaCl–KCl salt media. The product exhibits a higher specific surface area and three-
Minzhong Huang, Wanyi Zeng, Ziwen Zhu
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
International Journal of Photoenergy, 2014 A well-designed type of micron-sized hollow silver sphere was successfully synthesized by a simple hard-template method to be used as substrates for surface-enhanced Raman scattering. 4 Å molecular sieves were employed as a removable solid template.
Lixin Xia +7 more
doaj +1 more source