Results 81 to 90 of about 3,944,943 (340)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Temporal Lobe Epilepsy Etiological Classification

Pediatric Neurology Briefs, 1997
Clinical, EEG, and neuroimaging findings in a community-based cohort of 63 children with new-onset temporal lobe epilepsy (TLE) studied prospectively are reported from the Royal Children’s Hospital, Melbourne, Australia.
J Gordon Millichap
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy

Neural Regeneration Research
Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory, resistant to antiepileptic drugs, and has a high recurrence rate.
Feng Chen, Xi Dong, Zhenhuan Wang, Tongrui Wu, Liangpeng Wei, Yuanyuan Li, Kai Zhang, Zengguang Ma, Chao Tian, Jing Li, Jingyu Zhao, Wei Zhang, Aili Liu, Hui Shen   +13 more
doaj   +1 more source

Temporal Lobe Epilepsy: Electroclinical Features

Pediatric Neurology Briefs, 1993
Results of video-EEG, PET, MRI, and pathological findings in 14 children aged 16 months to 12 years who were seizure-free after temporal lobectomy are reported in a multicenter, international study at Cleveland, Singapore, Naples, and Helsinki.
J Gordon Millichap
doaj   +1 more source

Thalamotemporal alteration and postoperative seizures in temporal lobe epilepsy

Annals of Neurology, 2015
There are competing explanations for persistent postoperative seizures after temporal lobe surgery. One is that 1 or more particular subtypes of mesial temporal lobe epilepsy (mTLE) exist that are particularly resistant to surgery.
S. Keller, M. Richardson, Jan-Christoph Schoene-Bake, J. O’Muircheartaigh, S. Elkommos, Barbara A. K. Kreilkamp, Y. Goh, A. Marson, C. Elger, B. Weber   +9 more
semanticscholar   +1 more source

Doublecortin-expressing cell types in temporal lobe epilepsy [PDF]

, 2018
Doublecortin (DCX) is widely regarded as a marker of immature and migrating neurons during development. While DCX expression persists in adults, particularly in the temporal lobe and neurogenic regions, it is unknown how seizures influence its expression.
Liu, J.Y.W., Cheryl Reeves, Matarin, Mar, Reeves, Cheryl, McEvoy, A.W., Sisodiya, S.M., Joan Y. W. Liu, Matarin, M., Thompson, P., Thom, M., Reeves, C., Matarin, M, Miserocchi, Anna, Liu, JYW, Maria Thom, Thompson, Pamela, Miserocchi, A, McEvoy, AW, Miserocchi, A., Anna Miserocchi, McEvoy, Andrew W., Sisodiya, Sanjay M., Mar Matarin, Reeves, C, Thom, Maria, Sisodiya, SM, Thom, M, Pamela Thompson, Liu, Joan Y. W., Thompson, P, Andrew W. McEvoy, Sanjay M. Sisodiya   +31 more
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Diffusion tensor tractography studies on mechanisms of recovery of injured fornix

Neural Regeneration Research, 2017
The fornix, which connects the medial temporal lobe and the medial diencephalon, is involved in episodic memory as an important part of the Papez circuit.
Sung Ho Jang, Han Do Lee
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source